Detailed information of TA system TA160910

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 91507..91933
• Replicon: plasmid unnamed1
• Accession: NZ_CP055001
• Organism: Shigella flexneri strain STIN_80

Toxin (Protein)

• Gene name: hok
• Uniprot ID: -
• Locus tag: HUZ55_RS24040
• Protein ID: WP_001372321.1
• Coordinates: 91507..91632 (-)
• Length: 42 a.a.

Antitoxin (RNA)

Gene name	sok
Locus tag	-
Coordinates	91709..91933 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUZ55_RS24000 (86876)	86876..87565	-	690	WP_039002187.1	conjugal transfer transcriptional regulator TraJ	-
HUZ55_RS24005 (87752)	87752..88135	-	384	WP_001151524.1	conjugal transfer relaxosome DNA-binding protein TraM	-
HUZ55_RS24010 (88456)	88456..89058	+	603	WP_000243712.1	transglycosylase SLT domain-containing protein	-
HUZ55_RS24015 (89355)	89355..90176	-	822	WP_072795862.1	DUF932 domain-containing protein	-
HUZ55_RS24020 (90298)	90298..90585	-	288	WP_000107535.1	hypothetical protein	-
HUZ55_RS24025 (90610)	90610..90816	-	207	WP_000547968.1	hypothetical protein	-
HUZ55_RS24030 (90886)	90886..91059	+	174	Protein_103	hypothetical protein	-
HUZ55_RS24035 (91057)	91057..91287	-	231	WP_001426396.1	hypothetical protein	-
HUZ55_RS24040 (91507)	91507..91632	-	126	WP_001372321.1	type I toxin-antitoxin system Hok family toxin	Toxin
HUZ55_RS24045 (91574)	91574..91723	-	150	Protein_106	plasmid maintenance protein Mok	-
- (91709)	91709..91933	-	225	NuclAT_0	-	Antitoxin
- (91709)	91709..91933	-	225	NuclAT_0	-	Antitoxin
- (91709)	91709..91933	-	225	NuclAT_0	-	Antitoxin
- (91709)	91709..91933	-	225	NuclAT_0	-	Antitoxin
HUZ55_RS24050 (91745)	91745..91933	+	189	WP_001299721.1	hypothetical protein	-
HUZ55_RS24055 (91945)	91945..92664	-	720	WP_001276232.1	plasmid SOS inhibition protein A	-
HUZ55_RS24060 (92661)	92661..93095	-	435	WP_000845953.1	conjugation system SOS inhibitor PsiB	-
HUZ55_RS24065 (93150)	93150..95108	-	1959	WP_039000998.1	ParB/RepB/Spo0J family partition protein	-
HUZ55_RS24070 (95173)	95173..95406	-	234	WP_000005987.1	DUF905 family protein	-
HUZ55_RS24075 (95463)	95463..96002	-	540	WP_032332913.1	single-stranded DNA-binding protein	-
HUZ55_RS24080 (96028)	96028..96234	-	207	WP_000275853.1	hypothetical protein	-
HUZ55_RS24085 (96475)	96475..96702	-	228	WP_071961421.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	tet(M) / ant(3'')-Ia / cmlA1 / aadA2 / dfrA12 / floR / sul2 / tet(A) / aph(3')-Ia / sul3 / blaTEM-1B / lnu(F) / aac(3)-IId	-	1..132056	132056

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (2-37)

Sequences

Toxin

Protein

• Length: 42 a.a.
• Molecular weight: 4780.69 Da
• Isoelectric Point: 8.5110

>T160910 WP_001372321.1 NZ_CP055001:c91632-91507 [Shigella flexneri]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Nucleotide

• Length: 126 bp

>T160910 NZ_CP070963:c26719-26585 [Escherichia coli]
ATGACGAAATATACCCTTATCGGGTTGCTTGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACAGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTGA

Antitoxin

Nucleotide

• Length: 225 bp

>AT160910 NZ_CP055001:c91933-91709 [Shigella flexneri]
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT

Structures

Antitoxin