Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2310110..2310636 | Replicon | chromosome |
| Accession | NZ_CP054992 | ||
| Organism | Shigella flexneri strain STIN_87 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | HUZ57_RS11330 | Protein ID | WP_000323025.1 |
| Coordinates | 2310349..2310636 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | HUZ57_RS11325 | Protein ID | WP_000534858.1 |
| Coordinates | 2310110..2310349 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HUZ57_RS11295 (2305469) | 2305469..2305816 | - | 348 | WP_000612626.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| HUZ57_RS11300 (2305813) | 2305813..2306217 | - | 405 | WP_000839179.1 | transposase | - |
| HUZ57_RS11305 (2306439) | 2306439..2306860 | + | 422 | Protein_2220 | hypothetical protein | - |
| HUZ57_RS11310 (2307495) | 2307495..2308808 | + | 1314 | WP_000589005.1 | ISNCY family transposase | - |
| HUZ57_RS11315 (2309245) | 2309245..2309577 | - | 333 | WP_001301033.1 | FlxA-like family protein | - |
| HUZ57_RS11320 (2309780) | 2309780..2310085 | - | 306 | WP_001326990.1 | protein YdfV | - |
| HUZ57_RS11325 (2310110) | 2310110..2310349 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| HUZ57_RS11330 (2310349) | 2310349..2310636 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| HUZ57_RS11335 (2310708) | 2310708..2310863 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| HUZ57_RS11340 (2311080) | 2311080..2311331 | + | 252 | WP_000980994.1 | protein Rem | - |
| HUZ57_RS11345 (2311398) | 2311398..2311676 | + | 279 | WP_012304870.1 | hypothetical protein | - |
| HUZ57_RS11350 (2311678) | 2311678..2312727 | + | 1050 | WP_001265199.1 | DUF968 domain-containing protein | - |
| HUZ57_RS11355 (2312741) | 2312741..2313211 | + | 471 | Protein_2230 | antitermination protein | - |
| HUZ57_RS11360 (2313266) | 2313266..2313963 | + | 698 | WP_106423973.1 | IS1 family transposase | - |
| HUZ57_RS11365 (2313977) | 2313977..2314081 | - | 105 | Protein_2232 | putative zinc-binding protein YnfU | - |
| HUZ57_RS11370 (2314301) | 2314301..2314516 | + | 216 | WP_000839590.1 | phage lysis protein EssD | - |
| HUZ57_RS11375 (2314521) | 2314521..2314832 | + | 312 | WP_000189916.1 | YdfR family protein | - |
| HUZ57_RS11380 (2314829) | 2314829..2315362 | + | 534 | WP_001092971.1 | lysozyme | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2277666..2362482 | 84816 | |
| - | flank | IS/Tn | - | - | 2313670..2313963 | 293 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T160849 WP_000323025.1 NZ_CP054992:2310349-2310636 [Shigella flexneri]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T160849 NZ_CP070954:1021027-1021434 [Escherichia fergusonii]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCCTGGCGCGCGCAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGTTAAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGACGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCGCCGTGGATGATTAAAAGCGGCATGATGTTGCGTTTACGTTCTGATAGCGGTAAACGTCA
GCACTTGTGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCCTGGCGCGCGCAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGTTAAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGACGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCGCCGTGGATGATTAAAAGCGGCATGATGTTGCGTTTACGTTCTGATAGCGGTAAACGTCA
GCACTTGTGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT160849 WP_000534858.1 NZ_CP054992:2310110-2310349 [Shigella flexneri]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT160849 NZ_CP070954:1020780-1021046 [Escherichia fergusonii]
ATGGACATTAATAACAAAGCCCGCATTCACTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGTGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCCGATC
TGTTCAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAATAACAAAGCCCGCATTCACTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGTGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCCGATC
TGTTCAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|