Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2237016..2237851 Replicon chromosome
Accession NZ_CP054940
Organism Escherichia coli strain MS6192

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1U9SHU4
Locus tag MS6192_RS10960 Protein ID WP_000854752.1
Coordinates 2237474..2237851 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID E3PJ72
Locus tag MS6192_RS10955 Protein ID WP_001278232.1
Coordinates 2237016..2237384 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MS6192_RS10915 2232758..2233108 - 351 WP_000624722.1 IS66 family insertion sequence element accessory protein TnpB -
MS6192_RS10920 2233105..2233530 - 426 WP_000422741.1 IS66 family insertion sequence hypothetical protein -
MS6192_RS10925 2233852..2234307 + 456 WP_000581504.1 hypothetical protein -
MS6192_RS10930 2234386..2234619 + 234 WP_001119729.1 DUF905 family protein -
MS6192_RS10935 2234719..2235537 + 819 WP_001234620.1 DUF945 domain-containing protein -
MS6192_RS10940 2235592..2236077 + 486 WP_000849582.1 antirestriction protein -
MS6192_RS10945 2236093..2236569 + 477 WP_001347688.1 RadC family protein -
MS6192_RS10950 2236632..2236853 + 222 WP_000692329.1 DUF987 domain-containing protein -
MS6192_RS10955 2237016..2237384 + 369 WP_001278232.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
MS6192_RS10960 2237474..2237851 + 378 WP_000854752.1 TA system toxin CbtA family protein Toxin
MS6192_RS10965 2237848..2238051 + 204 WP_000761705.1 hypothetical protein -
MS6192_RS10970 2238064..2238177 + 114 WP_001161660.1 DUF957 domain-containing protein -
MS6192_RS10975 2238336..2239364 + 1029 Protein_2147 IS110 family transposase -
MS6192_RS10980 2239818..2240000 + 183 WP_024167529.1 ethanolamine utilization protein -
MS6192_RS10985 2240101..2240430 - 330 WP_000450409.1 DUF496 family protein -
MS6192_RS10990 2240602..2241660 - 1059 WP_074499974.1 FUSC family protein -
MS6192_RS10995 2241859..2242332 - 474 WP_001105393.1 DNA gyrase inhibitor SbmC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14076.08 Da        Isoelectric Point: 8.2905

>T160667 WP_000854752.1 NZ_CP054940:2237474-2237851 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T160667 NZ_CP070844:509128-509478 [Bacillus subtilis subsp. natto]
TTGATTGTGAAACGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGGGTGCGCCCGGT
CTTAGTGATCCAAAATGACATCGGAAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCACAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATCGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGGTTAACGGATAAGATTACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13491.37 Da        Isoelectric Point: 6.6290

>AT160667 WP_001278232.1 NZ_CP054940:2237016-2237384 [Escherichia coli]
VSDALSGTMLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT160667 NZ_CP070844:508842-509123 [Bacillus subtilis subsp. natto]
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCCGAAAACCTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCATATGTCAGCGAACGAACAACTCGTCACAACC
GTGATTTGATGAGACGCGGCTATATGGAAATGGCGAAAATCAACCTGAATATTTCTTCTGAGGCTCACTTTGCGGAGTGC
GAGGCTGAAACGACAGTTGAGCGCTTAGTCAGCGGAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1U9SHU4

Antitoxin

Source ID Structure
AlphaFold DB E3PJ72

References