Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 2754747..2754972 Replicon chromosome
Accession NZ_CP054913
Organism Shigella flexneri strain FDAARGOS_691

Toxin (Protein)


Gene name hokW Uniprot ID -
Locus tag FOB99_RS13670 Protein ID WP_000018421.1
Coordinates 2754760..2754972 (+) Length 71 a.a.

Antitoxin (RNA)


Gene name sokW
Locus tag -
Coordinates 2754747..2754805 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOB99_RS13630 2750313..2750567 + 255 Protein_2643 hypothetical protein -
FOB99_RS13635 2751060..2751806 + 747 WP_000788996.1 ATP-binding protein -
FOB99_RS13640 2751821..2752243 + 423 WP_001118167.1 DUF977 family protein -
FOB99_RS13645 2752301..2752657 + 357 WP_005048249.1 hypothetical protein -
FOB99_RS13650 2752750..2752968 + 219 WP_000256998.1 DUF4014 family protein -
FOB99_RS13655 2752970..2753335 + 366 WP_001229297.1 HNH endonuclease -
FOB99_RS13660 2753332..2753997 + 666 WP_000208062.1 hypothetical protein -
FOB99_RS13665 2753997..2754362 + 366 WP_000610655.1 DUF551 domain-containing protein -
- 2754747..2754805 - 59 - - Antitoxin
FOB99_RS13670 2754760..2754972 + 213 WP_000018421.1 type I toxin-antitoxin system Hok family toxin Toxin
FOB99_RS13675 2755478..2756175 - 698 Protein_2652 IS1 family transposase -
FOB99_RS13680 2756204..2756680 - 477 WP_000156246.1 DUF986 family protein -
FOB99_RS13685 2756735..2757586 - 852 WP_001331209.1 PTS mannose transporter subunit IID -
FOB99_RS13690 2757599..2758399 - 801 WP_000406926.1 PTS mannose transporter subunit IIC -
FOB99_RS13695 2758462..2759433 - 972 WP_000150543.1 PTS mannose transporter subunit IIAB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2741715..2755981 14266
flank IS/Tn - - 2755478..2755981 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(25-66)


Sequences

Toxin        


Download         Length: 71 a.a.        Molecular weight: 7880.44 Da        Isoelectric Point: 9.2663

>T160613 WP_000018421.1 NZ_CP054913:2754760-2754972 [Shigella flexneri]
MSHKCRLASYVPKGKEKQAMKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Download         Length: 213 bp

>T160613 NZ_CP070593:1052578-1052880 [Escherichia coli]
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA

Antitoxin


Download         Length: 59 bp

>AT160613 NZ_CP054913:c2754805-2754747 [Shigella flexneri]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATTTGTGAGACATAGATTGGGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References