Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3084592..3085840 Replicon chromosome
Accession NZ_CP054871
Organism Pseudomonas protegens strain PPRAR07

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HUT23_RS14335 Protein ID WP_210482173.1
Coordinates 3085268..3085840 (+) Length 191 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HUT23_RS14330 Protein ID WP_210482174.1
Coordinates 3084592..3085149 (+) Length 186 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUT23_RS14300 (HUT23_14315) 3079796..3080446 + 651 WP_210482176.1 DUF2239 family protein -
HUT23_RS14305 (HUT23_14320) 3080534..3081154 + 621 WP_011060979.1 LysE family translocator -
HUT23_RS14310 (HUT23_14325) 3081200..3081787 - 588 WP_011060980.1 AidA/PixA family protein -
HUT23_RS14315 (HUT23_14330) 3082247..3083434 + 1188 WP_077933989.1 PrpF domain-containing protein -
HUT23_RS14320 (HUT23_14335) 3083613..3084059 - 447 WP_228102409.1 hypothetical protein -
HUT23_RS14325 (HUT23_14340) 3084061..3084402 - 342 WP_210482175.1 low molecular weight protein tyrosine phosphatase family protein -
HUT23_RS14330 (HUT23_14345) 3084592..3085149 + 558 WP_210482174.1 helix-turn-helix transcriptional regulator Antitoxin
HUT23_RS14335 (HUT23_14350) 3085268..3085840 + 573 WP_210482173.1 HD domain-containing protein Toxin
HUT23_RS14340 (HUT23_14355) 3086095..3088275 + 2181 WP_210482172.1 catalase/peroxidase HPI -
HUT23_RS14345 (HUT23_14360) 3088403..3088831 - 429 WP_125063949.1 hypothetical protein -
HUT23_RS14350 (HUT23_14365) 3089066..3089980 + 915 WP_210456777.1 SGNH/GDSL hydrolase family protein -
HUT23_RS14355 (HUT23_14370) 3090301..3090564 + 264 WP_210456776.1 hypothetical protein -
HUT23_RS14360 (HUT23_14375) 3090567..3090755 + 189 WP_236203763.1 DUF6360 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(8-147)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-46)


Sequences

Toxin        


Download         Length: 191 a.a.        Molecular weight: 21385.03 Da        Isoelectric Point: 4.9459

>T160554 WP_210482173.1 NZ_CP054871:3085268-3085840 [Pseudomonas protegens]
MNSELLSGRLDFLREAEKLKDVLRSAHTSSGRQESTAEHSWRLCLMALLFEDQLGDLDLLRVLKLCIVHDLGEAIHGDIP
AVVQAAHPDKSQQERADLQLLARALDAPAREHLLELWDEYEGAASAEAQTVKALDKLETLLQHTQGQNPAGFDYRFNLGY
GRRYTDASPLFQALRQQIDIDTQRRLDAQG

Download         Length: 573 bp

>T160554 NZ_CP070569:c97438-96125 [Proteus mirabilis]
ATGGCGAGTCTTGATGTATATATGAATGAATACTATGTGGGTATCTTTACTAAAAAAAGCTCAGGTGCGCATTCATTCCA
ATATACTGAAGATTGGGTTAATCAACCAGGAAGTCGTCCCATCTCTCTATCGATGCCATTACAACTTCAAGAATATCAAG
GAGACTGTGTCTATAATTTCTTTGATAATCTATTACCTGATAATACTGAAATTAGAAATCGTATTGTGAGTCGCTATAAT
GCGAACTCAAATCAACCCTTTGACCTATTAGTGGCTATCGGTGCAGATACTGTTGGTGCATTAAGGTTACTTCCTAGTGG
CAGTACGCCTGCGAATATCAAAAAAATAGAATATCAAAAACTCAATGATATTGAGCTTGAAAAAATTCTACTAGGATATA
AATCCAATACTCCACTCGGTATGCTTAAAAAATATACTGATTTCAGAATTTCCATCGCTGGAGCACAAGAAAAAACGGCA
TTACTTTTAAAAGATAATGATTGGTGTGTGCCACATAATAACACACCAACTACCCATATTATTAAACTGCCAATTGGTGT
TATTGAAAGTCATTCTTATACAATGGATTTATCCAATAGTGTAGAAAATGAGTATCTTTGTACCTTAATTGCCAAAGAAT
TTGATCTTCCCGTCCCCCACTGCTCTATTATTAAAACAAAAAATGTTAAAGCGCTTGCTGTAGAACGTTTTGATAGAAAA
TATTCATCTGATAAATCGTGGATAATACGTTTACCTCAAGAAGATTTTTGCCAAATTTTAAATATACCTTCTGCGCTAAA
ATATGAAAATGAAGGAGGGCCTGGCATTATCGATATTATGAAATATTTACTTGGCTCATCAAATGCCGATCAAGATCGTT
TTCATTTTATGAAGGCACAAGTGCTATTTTGGCTTTTGGCTGCAACGGATGGACACGCAAAAAATTTTTCTGTTTTTATC
AACCAAGAAGGACGTTTCCATCTCACTCCTCTTTATGACATTATGTCCATCTATCCCAATTTCGGAGGACGAGGACTTAA
TCCACGAGATGCAAAACTTGCTATGGGATTAAAAGCAAGCCGAGGCAAAAAATACGCAATAGAACAAATTTTTCCTCGTC
ATTTCTACCAAACAGCTGAAGCTGTCGGTTTCGATCCTTCATTAATGAGCGATATTCTTCGTTATTTTTATCAAGAAATG
GACGATGTCATACAACGCGTAAAACAGCAATTACCCGAGGATTTCCCTTCTGAGATTAGCAATACAATATTAGATGGAAT
GAAAGCACGCGCTGTTAGATTAGCTAACATTTAG

Antitoxin


Download         Length: 186 a.a.        Molecular weight: 20349.28 Da        Isoelectric Point: 7.7817

>AT160554 WP_210482174.1 NZ_CP054871:3084592-3085149 [Pseudomonas protegens]
MPAAPFTSPHLGLALRRWRLLHRVKQQHAAELFGVAQSSISRWENGQQAMEPAERVRLEQLLAANLSAAADQALARLVND
SPRAVHLVCDLTHRLLACSATRAGQFGVPLSELLGQSLWGFCTEEITRKEAALDDLGWRSLLAPPSVEFFSGHNDSAIVP
IAPSRCRWTRLNLSDGNAVRLVETL

Download         Length: 558 bp

>AT160554 NZ_CP070569:c97696-97439 [Proteus mirabilis]
ATGATCATAATTAATGCCTATCAACTCAGTGTGCATCTAAAAGATGTCCGATTAACAAAAAAACTGTCTCAAAGTAAAGT
CGCCCAAAAAGTAGGGATCCGACAAGATACCGTGTCCAATTTTGAAATTAATCCTAATTCCACCAAACTAGAAACCTTTT
TCAAACTGCTCTCCGCACTAAATTTAGAGATGGAAATTCATCCTAAAGATGCTAAAAATAATTTAGCACACAAAAGTGAA
TGGAAAGAGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References