Detailed information of TA system TA160530

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumA-relB/upstrm_HI1419-dnstrm_HI1420
• Location: 1994875..1995485
• Replicon: chromosome
• Accession: NZ_CP054861
• Organism: Martelella sp. NC20

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: -
• Locus tag: HQ843_RS09600
• Protein ID: WP_180898519.1
• Coordinates: 1994875..1995168 (+)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HQ843_RS09605
• Protein ID: WP_180898518.1
• Coordinates: 1995165..1995485 (+)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HQ843_RS09585	1990475..1991884	-	1410	WP_180898523.1	MFS transporter	-
HQ843_RS09590	1992075..1993064	+	990	WP_180898521.1	MBL fold metallo-hydrolase	-
HQ843_RS09595	1993248..1994750	+	1503	WP_180898520.1	IMP dehydrogenase	-
HQ843_RS09600	1994875..1995168	+	294	WP_180898519.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HQ843_RS09605	1995165..1995485	+	321	WP_180898518.1	putative addiction module antidote protein	Antitoxin
HQ843_RS09610	1995495..1996313	-	819	WP_180898517.1	transglutaminase family protein	-
HQ843_RS09615	1996343..1997281	-	939	WP_180898516.1	alpha-E domain-containing protein	-
HQ843_RS09620	1997284..1998705	-	1422	WP_180898515.1	circularly permuted type 2 ATP-grasp protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (4-94)

Antitoxin

• Uncharacterized protein HI1420 (10-100)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 10913.53 Da
• Isoelectric Point: 10.2993

>T160530 WP_180898519.1 NZ_CP054861:1994875-1995168 [Martelella sp. NC20]
MSEVLQTGAFSAWLSDLRDREARARIIARIRRIEQGNLGDVKSLGNGLGEVRIHHGPGYRLYFCRRGEAIVILLCGGDKS
AQERDIQRAREFLKGMS

Nucleotide

• Length: 294 bp

>T160530 NZ_CP070562:64240-64722 [Klebsiella pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 11187.65 Da
• Isoelectric Point: 4.5341

>AT160530 WP_180898518.1 NZ_CP054861:1995165-1995485 [Martelella sp. NC20]
MTEIGKHAELTPFDAAGYLETPEDIAFYLEAVLEDGDPALIAAALGDVARSKGMSAVSRRAGVTREALYKALSENGDPKL
STLIGVLKALGLQLAVRPENHHDDAA

Nucleotide

• Length: 321 bp

>AT160530 NZ_CP070562:63986-64252 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA