Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 143250..143755 Replicon chromosome
Accession NZ_CP054789
Organism Pseudomonas aeruginosa strain SE5381

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag HUK70_RS00660 Protein ID WP_003083773.1
Coordinates 143250..143531 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag HUK70_RS00665 Protein ID WP_003083775.1
Coordinates 143528..143755 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUK70_RS00635 (HUK70_00635) 138501..139850 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
HUK70_RS00640 (HUK70_00640) 139899..140585 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
HUK70_RS00645 (HUK70_00645) 140686..141420 + 735 WP_003117208.1 GntR family transcriptional regulator -
HUK70_RS00650 (HUK70_00650) 141600..142010 + 411 WP_003101225.1 aegerolysin family protein -
HUK70_RS00655 (HUK70_00655) 142042..142950 - 909 WP_010793581.1 LysR family transcriptional regulator -
HUK70_RS00660 (HUK70_00660) 143250..143531 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
HUK70_RS00665 (HUK70_00665) 143528..143755 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
HUK70_RS00670 (HUK70_00670) 143931..144551 - 621 WP_003101226.1 hypothetical protein -
HUK70_RS00675 (HUK70_00675) 144652..145152 + 501 WP_003101228.1 LEA type 2 family protein -
HUK70_RS00680 (HUK70_00680) 145225..145566 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
HUK70_RS00685 (HUK70_00685) 145648..147075 - 1428 WP_003083784.1 GABA permease -
HUK70_RS00690 (HUK70_00690) 147244..148737 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T160445 WP_003083773.1 NZ_CP054789:c143531-143250 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T160445 NZ_CP070505:c831754-831185 [Pseudomonas toyotomiensis]
ATGTTCAAGCCGCAGCTGGTGACTTTGCAACGTGGCGCTCTGCGCCTGGAACCGCTCTCTGACGCGGATATCCCCGCGCT
GGTGGCGCTGGCCGAAGCCAATCGCGAGGAGCTGCTGTACATGAGCGGCACCCAGCGACTGGACTGGTACCGCAGCGCCC
TGGCCGATATGCGCGAGCAGCGGGCACTGCCATTCGTCATTCGTCTGGGTGACGAGTTGGTAGGCACCACCCGCTTCGCC
GACTTCATGAACACCCTGCCGGCCTGTGAAATCGGCTGGACCTGGCTCGACCGCGGCCAGCATGGCAGCGGGTTGAACGC
CAGCATCAAGTATTTGATGCTCAAGCACGCTTTCGAAAATTGGGGCATGGTTCGCGTGCAACTGAAAACCGCCGCCAGCA
ACCTGCGTTCGCAACGCGCCATCGAGAAGCTTGGCGCCGTTCGTGAAGGGTTGCTGCGCAACCATCGCCGTCTGGCTGAT
GGCCGACTCGATGACACCGTGCTGTACAGCATCACCGATCTGGAATGGCCGGCGCTGCGTGAGGCAATGGAGGCGGGCTT
CAACGCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT160445 WP_003083775.1 NZ_CP054789:c143755-143528 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT160445 NZ_CP070505:c831179-830352 [Pseudomonas toyotomiensis]
ATGCACAGTCGCGAGCAGACCCGCTTCTGGCAAGCTTCCGCCTTGAGCGGCGTCGAGCTGTTGCAGGCGCGCTACCTTGA
ACAGCGCTTCGCGCCCCACGTGCATGAAGGTTTCGTGTTCACCGTGATCGAGCATGGCGCCCAGCGCTTTCGTCATCGCG
GTTGTGATCATCTGGCACCGCAGGGCAGCATGGTGCTGATCAACCCGGACGAAGTGCACACCGGCTCCAAGGCGCACGAA
GACGGTTGGCGCTATCGCGGTTTCTATCCCGACAACGCCTATGTACTGGGGGTGCTGCAGGAGCTGGGCCTGGTCAAGGC
TGGCATGCCGTCGTTTGCCTTCAGCGTGCTGCATGATCCACGTTTGCATGCGGCCTTTCTGCAACTGCACCAACTGCTCG
AGGGTGGTGCCGAGGCACTGCAGCAGCAACTGGCCTGGCGTGAGGCGATTCTGCTGCTGTTTCAGCATCATGCGCAGCTT
GCCGAACCACCTGCGCCTGGGCGTGAGCCATGGGCAGTGGCCTGCGCCAAGCAGATGCTTGCCGAACGCCTGGTCGAGCC
GCCGTCTCTGGAAGAGCTGGCGGCTGCGGTTAGCCTCTCTCCTTTTCACTTCGCGCGCGTATTTCGCCGCGCGACCGGCT
TGCCGCCGCATGCCTGGCTCAAGCAGCGACGCCTGGAACAGGCGCGGGCGTTGCTCAAGACGGGCTGTACGGCGGTCGCT
GTGGCCATGCAGTTGGGCTTCGCCGATCAGAGCCACTTGTCGCGGCAGTTCAAGCAGGTTTATGGCGTGAGCCCTGGCGA
ATATCGCAGCGCGGTGGCCCGGAGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References