Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 1959506..1961014 Replicon chromosome
Accession NZ_CP054787
Organism Pseudomonas aeruginosa strain HB2011305RE

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag HUK67_RS09375 Protein ID WP_003119682.1
Coordinates 1959506..1960093 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A9E8LAI1
Locus tag HUK67_RS09380 Protein ID WP_003117606.1
Coordinates 1960160..1961014 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUK67_RS09370 (HUK67_09375) 1955761..1959240 - 3480 WP_003117605.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -
HUK67_RS09375 (HUK67_09380) 1959506..1960093 + 588 WP_003119682.1 GNAT family protein Toxin
HUK67_RS09380 (HUK67_09385) 1960160..1961014 + 855 WP_003117606.1 AraC family transcriptional regulator Antitoxin
HUK67_RS09385 (HUK67_09390) 1961111..1963276 + 2166 WP_015649209.1 TonB-dependent receptor family protein -
HUK67_RS09390 (HUK67_09395) 1963451..1965325 + 1875 WP_003117607.1 MFS transporter -
HUK67_RS09395 (HUK67_09400) 1965386..1965595 - 210 WP_003115568.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T160431 WP_003119682.1 NZ_CP054787:1959506-1960093 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

>T160431 NZ_CP070499:c4788556-4788161 [Natronosporangium hydrolyticum]
GTGACGAGCTTGCTGGACGCCAACGTCCTGATCGCGCTGCTCAACACAGACCACGTTCATCACCGAGCGGCCCAGCGATG
GTTTGTTGATCTCCAGGAGAGCTTCGCCACCTGTCCTGTCACCGAGGGAGCGCTGGCCCGATTCGCATTCCGTGCTGGGA
AGGCCGCCGAAGATGTCGAGCAGCTCATCGGCATGGTGGCGCAACATCCCCGCCGGGAGTTCTGGCCGGACAGCCTTCCG
TATGACAGAGTCGCCTTCAAGGGCGTCATCGGTCACCGGCAGGTGACCGACGCCTATCTCGCTCAGTTGGCTCGGGCCAA
CGGCGGCCGTCTCGCAACCTTCGACAAAGGCCTCGCGCAATTCCACGGCGATGTCGCGGAGCTCATACCCGTGTGA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31863.14 Da        Isoelectric Point: 7.5295

>AT160431 WP_003117606.1 NZ_CP054787:1960160-1961014 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETVLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTTYE

Download         Length: 855 bp

>AT160431 NZ_CP070499:c4788786-4788553 [Natronosporangium hydrolyticum]
ATGCGTACGACCATCGACCTTCCGCCGGATCTGCATCAGCAGGCACTTGCCATCGCTCGCGACACGTCCCGAACGCTGAG
TGAGACCGTCGCAGATCTGATGCGACGGGCTCTCGGCCAAGGGCAGCCGAGCGACTCGCCTATCACCCGGGACGAGCTGA
CCGGTTTGCCGGTCTTCAGTGTCGGCAAGGTCATCACCACGGAGGATGTGCGGTCCCTGGAGGACGACGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure

References