Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1564079..1564735 Replicon chromosome
Accession NZ_CP054787
Organism Pseudomonas aeruginosa strain HB2011305RE

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag HUK67_RS07495 Protein ID WP_033971890.1
Coordinates 1564553..1564735 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HUK67_RS07490 Protein ID WP_023875730.1
Coordinates 1564079..1564507 (-) Length 143 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUK67_RS07450 (HUK67_07450) 1560122..1560835 + 714 WP_003159463.1 phage antirepressor KilAC domain-containing protein -
HUK67_RS07455 (HUK67_07455) 1560900..1561661 + 762 WP_198580818.1 helix-turn-helix domain-containing protein -
HUK67_RS07460 (HUK67_07460) 1561658..1562341 + 684 WP_198580819.1 replication protein P -
HUK67_RS07465 (HUK67_07465) 1562338..1562544 + 207 WP_198580820.1 hypothetical protein -
HUK67_RS07470 (HUK67_07470) 1562541..1562912 + 372 WP_121147581.1 Ref family recombination enhancement nuclease -
HUK67_RS07475 (HUK67_07475) 1562909..1563256 + 348 WP_058161108.1 RusA family crossover junction endodeoxyribonuclease -
HUK67_RS07480 (HUK67_07480) 1563253..1563552 + 300 WP_073652357.1 hypothetical protein -
HUK67_RS07485 (HUK67_07485) 1563554..1563928 + 375 WP_016852550.1 antiterminator Q family protein -
HUK67_RS07490 (HUK67_07490) 1564079..1564507 - 429 WP_023875730.1 transcriptional regulator Antitoxin
HUK67_RS07495 (HUK67_07495) 1564553..1564735 - 183 WP_033971890.1 type II toxin-antitoxin system HicA family toxin Toxin
HUK67_RS07500 (HUK67_07500) 1564935..1565267 + 333 WP_043494869.1 phage holin, lambda family -
HUK67_RS07505 (HUK67_07505) 1565264..1565881 + 618 WP_128542531.1 glycoside hydrolase family 19 protein -
HUK67_RS07510 (HUK67_07510) 1565878..1566120 + 243 WP_023875728.1 hypothetical protein -
HUK67_RS07515 (HUK67_07515) 1566117..1566587 + 471 WP_124173773.1 lysis system i-spanin subunit Rz -
HUK67_RS07520 (HUK67_07520) 1566584..1567327 + 744 WP_128542530.1 hypothetical protein -
HUK67_RS07525 (HUK67_07525) 1567459..1567986 + 528 WP_058143933.1 terminase small subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1535106..1595233 60127


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(7-78)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6776.89 Da        Isoelectric Point: 11.0775

>T160430 WP_033971890.1 NZ_CP054787:c1564735-1564553 [Pseudomonas aeruginosa]
MKFSEFRRWLKAQGVTFEAGKGSHFKITAPNGKQTTFADHGTKEMPEPTRKAIIKQLGLK

Download         Length: 183 bp

>T160430 NZ_CP070499:4605937-4606224 [Natronosporangium hydrolyticum]
TTGATCGCTTCGTTCGGCGACGCAGCGACGGAGGCCTTGTTCCACGGACGCACCAGCCGCGCCCGGCGCATCCCAGCCAA
CATCCGCGCTGCGGCGCTCCGGAAGCTGGATATGGTCAACGCGGCCCGGGAGCTTCGTGACCTGCGGGTACCGCCGGGTA
ACCGGTTGGAGGCGTTGAAGGGAGACCGTGCAGGAGACCACAGCATCCGGGTAAACGACCAGTGGCGCATCGTCTTCCGT
TGGGAGAGCGGAGACGCGCACGAGGTCACGATCGTCGACTACCACTGA

Antitoxin


Download         Length: 143 a.a.        Molecular weight: 15758.92 Da        Isoelectric Point: 4.6562

>AT160430 WP_023875730.1 NZ_CP054787:c1564507-1564079 [Pseudomonas aeruginosa]
MYDYAIRFEQDDSAPGVAVFCRDLPELNSYGDDKAHAISEAVDAIESTLSLYVDQRREIPAASQAQPGERVIHLPAVTVA
KIALWNEMVRRDMRKADLCRLLGIAQTQGDRLVDFLHNTKMEAMENALSALGLRLSVNIEAA

Download         Length: 429 bp

>AT160430 NZ_CP070499:4606234-4606521 [Natronosporangium hydrolyticum]
ATGCTGCCAGCGAACCGGATCCCAACCCACCCCGGTGAGGTCCTGAGCGAGGAGTTCCTCAAACCGCTCGGCTTGACTCA
GGTAGCACTGGCCGAGCACCTGGGCGTACCAGTTCAGCGAATCAACGAGCTTGTGCGTGGTAAGCGGGGCGTAACGCCGG
AGACCGCCTGGCTCCTGGCTGGCGCCTTCGGGACCACCCCTGACTTCTGGATCAACCTCCAGACCGCCCACGATCTAGCC
GTAACCAGGCCGACCCGGGGCGTCCCGCAGCTCGCTCAGGCGGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References