Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 2231692..2232275 Replicon chromosome
Accession NZ_CP054522
Organism Bifidobacterium longum subsp. infantis strain PI_007

Toxin (Protein)


Gene name PumA Uniprot ID A0A1S2VZ23
Locus tag HUE66_RS09650 Protein ID WP_032745284.1
Coordinates 2231973..2232275 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID I3AVV5
Locus tag HUE66_RS09645 Protein ID WP_007057517.1
Coordinates 2231692..2231976 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUE66_RS09620 (HUE66_09650) 2227836..2228204 - 369 WP_155270629.1 hypothetical protein -
HUE66_RS09625 (HUE66_09655) 2228198..2229280 + 1083 Protein_1873 transposase -
HUE66_RS09630 (HUE66_09660) 2229378..2230286 + 909 WP_032744304.1 ABC transporter ATP-binding protein -
HUE66_RS09635 (HUE66_09665) 2230283..2231014 + 732 WP_032744305.1 ABC transporter permease -
HUE66_RS09640 (HUE66_09670) 2231032..2231583 - 552 Protein_1876 IS30 family transposase -
HUE66_RS09645 (HUE66_09675) 2231692..2231976 - 285 WP_007057517.1 putative addiction module antidote protein Antitoxin
HUE66_RS09650 (HUE66_09680) 2231973..2232275 - 303 WP_032745284.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HUE66_RS09655 (HUE66_09685) 2232313..2232642 - 330 WP_257798116.1 DUF1922 domain-containing protein -
HUE66_RS09660 (HUE66_09690) 2232768..2233256 + 489 WP_032745281.1 D-aminoacyl-tRNA deacylase -
HUE66_RS09665 (HUE66_09695) 2233417..2236536 + 3120 WP_136527129.1 alpha-mannosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2231032..2231487 455


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(9-92)

Antitoxin

Uncharacterized protein HI1420

(3-92)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11350.08 Da        Isoelectric Point: 10.4626

>T159826 WP_032745284.1 NZ_CP054522:c2232275-2231973 [Bifidobacterium longum subsp. infantis]
IKQSAEYRKWFKKLRDHKAKAAIQARLDACKLAGRPFGDIKPVGGPVSEMRFHTGAGYRVYFAMQGNVLMLLLAGGDKST
QQTDIRQAHDILNDYKEQRQ

Download         Length: 303 bp

>T159826 NZ_CP070152:3326084-3326461 [Escherichia coli]
ATGAACACATTACCCGATACACACGTACGGGAGGCATCGCATTGCCAGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACTCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10158.37 Da        Isoelectric Point: 4.3707

>AT159826 WP_007057517.1 NZ_CP054522:c2231976-2231692 [Bifidobacterium longum subsp. infantis]
MSTEFTDYDTSEYLENEQDIIAYLNAIAEYDDPALMQAALGNVAKARGMTQIAKDAGVGRESLYKSLSKDGNPSFQTIAK
VIHALGGRLTIQAA

Download         Length: 285 bp

>AT159826 NZ_CP070152:3325626-3325994 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATAACGACCGCACCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAAGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1S2VZ23

Antitoxin

Source ID Structure
AlphaFold DB I3AVV5

References