Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-pasA/RelE-HTH
Location 562819..563308 Replicon chromosome
Accession NZ_CP054520
Organism Bifidobacterium longum subsp. infantis strain PI_009

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag HUE68_RS02505 Protein ID WP_229773994.1
Coordinates 562819..563046 (-) Length 76 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID A0A4V2N072
Locus tag HUE68_RS02510 Protein ID WP_032744823.1
Coordinates 563072..563308 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUE68_RS02490 (HUE68_02490) 560042..560764 - 723 WP_032744819.1 hypothetical protein -
HUE68_RS02495 (HUE68_02495) 560829..561785 - 957 WP_032744820.1 A/G-specific adenine glycosylase -
HUE68_RS02500 (HUE68_02500) 561806..562468 + 663 WP_136527151.1 tRNA (cytidine(34)-2'-O)-methyltransferase -
HUE68_RS02505 (HUE68_02505) 562819..563046 - 228 WP_229773994.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HUE68_RS02510 (HUE68_02510) 563072..563308 - 237 WP_032744823.1 ribbon-helix-helix domain-containing protein Antitoxin
HUE68_RS02515 (HUE68_02515) 563891..564604 - 714 WP_080714860.1 4'-phosphopantetheinyl transferase superfamily protein -
HUE68_RS02520 (HUE68_02520) 564615..565940 - 1326 WP_230581269.1 MFS transporter -
HUE68_RS02525 (HUE68_02525) 565967..567154 - 1188 WP_032744825.1 carboxylate--amine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 562819..572152 9333


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-72)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 76 a.a.        Molecular weight: 8653.22 Da        Isoelectric Point: 10.1818

>T159812 WP_229773994.1 NZ_CP054520:c563046-562819 [Bifidobacterium longum subsp. infantis]
MKKLDRNVAKRIIAKLREISQLEDPRSTGKALAGNLAGLWRYRVGDYRIVCDIEDEVLLILVIDVAHRSKVYKRC

Download         Length: 228 bp

>T159812 NZ_CP070148:c4486278-4486171 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCACGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8928.15 Da        Isoelectric Point: 4.2821

>AT159812 WP_032744823.1 NZ_CP054520:c563308-563072 [Bifidobacterium longum subsp. infantis]
MATVTAALRMPVELAARYDCLAKATGRTKTFYMNEALTESIDRFEYEYGIMKKVEDWRAGRLETVTLDELEESLGLED

Download         Length: 237 bp

>AT159812 NZ_CP070148:4486326-4486392 [Escherichia coli]
GGTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A4V2N072

References