Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 40225..40489 | Replicon | plasmid pSCU-204-2 |
| Accession | NZ_CP054413 | ||
| Organism | Escherichia coli strain SCU-204 | ||
Toxin (Protein)
| Gene name | pndA | Uniprot ID | U9Y6M3 |
| Locus tag | HHJ42_RS25370 | Protein ID | WP_001331364.1 |
| Coordinates | 40337..40489 (+) | Length | 51 a.a. |
Antitoxin (RNA)
| Gene name | pndB | ||
| Locus tag | - | ||
| Coordinates | 40225..40282 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HHJ42_RS25355 (35464) | 35464..37755 | - | 2292 | WP_001289276.1 | F-type conjugative transfer protein TrbC | - |
| HHJ42_RS25360 (37748) | 37748..38818 | - | 1071 | WP_000151583.1 | IncI1-type conjugal transfer protein TrbB | - |
| HHJ42_RS25365 (38837) | 38837..40045 | - | 1209 | WP_000121273.1 | IncI1-type conjugal transfer protein TrbA | - |
| - (40225) | 40225..40282 | - | 58 | NuclAT_0 | - | Antitoxin |
| - (40225) | 40225..40282 | - | 58 | NuclAT_0 | - | Antitoxin |
| - (40225) | 40225..40282 | - | 58 | NuclAT_0 | - | Antitoxin |
| - (40225) | 40225..40282 | - | 58 | NuclAT_0 | - | Antitoxin |
| HHJ42_RS25370 (40337) | 40337..40489 | + | 153 | WP_001331364.1 | Hok/Gef family protein | Toxin |
| HHJ42_RS25375 (40561) | 40561..40812 | - | 252 | WP_001291964.1 | hypothetical protein | - |
| HHJ42_RS26665 (41311) | 41311..41406 | + | 96 | WP_001303310.1 | DinQ-like type I toxin DqlB | - |
| HHJ42_RS25380 (41471) | 41471..41647 | - | 177 | WP_001054897.1 | hypothetical protein | - |
| HHJ42_RS25385 (42039) | 42039..42248 | + | 210 | WP_000062603.1 | HEAT repeat domain-containing protein | - |
| HHJ42_RS25390 (42320) | 42320..42970 | - | 651 | WP_032179289.1 | plasmid IncI1-type surface exclusion protein ExcA | - |
| HHJ42_RS25395 (43044) | 43044..45212 | - | 2169 | WP_171274544.1 | DotA/TraY family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | - | 1..86646 | 86646 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 51 a.a. Molecular weight: 5775.13 Da Isoelectric Point: 8.7948
>T159721 WP_001331364.1 NZ_CP054413:40337-40489 [Escherichia coli]
MPQRTFLMMLIVICVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR
MPQRTFLMMLIVICVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR
Download Length: 153 bp
>T159721 NZ_CP070115:2595331-2595738 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGCTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGCTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA
Antitoxin
Download Length: 58 bp
>AT159721 NZ_CP054413:c40282-40225 [Escherichia coli]
GCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
GCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
