Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4564804..4565320 Replicon chromosome
Accession NZ_CP054403
Organism Klebsiella pneumoniae strain KCJ3K292

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag FOH48_RS24100 Protein ID WP_004178374.1
Coordinates 4564804..4565088 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag FOH48_RS24105 Protein ID WP_002886901.1
Coordinates 4565078..4565320 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOH48_RS24075 (FOH48_024000) 4560288..4560551 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
FOH48_RS24080 (FOH48_024005) 4560681..4560854 + 174 WP_032408826.1 hypothetical protein -
FOH48_RS24085 (FOH48_024010) 4560857..4561600 + 744 WP_143873029.1 MurR/RpiR family transcriptional regulator -
FOH48_RS24090 (FOH48_024015) 4561957..4564095 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
FOH48_RS24095 (FOH48_024020) 4564336..4564800 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
FOH48_RS24100 (FOH48_024025) 4564804..4565088 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FOH48_RS24105 (FOH48_024030) 4565078..4565320 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FOH48_RS24110 (FOH48_024035) 4565398..4567308 - 1911 WP_143873031.1 PRD domain-containing protein -
FOH48_RS24115 (FOH48_024040) 4567331..4568485 - 1155 WP_002886900.1 lactonase family protein -
FOH48_RS24120 (FOH48_024045) 4568552..4569292 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T159637 WP_004178374.1 NZ_CP054403:c4565088-4564804 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T159637 NZ_CP070098:c4015761-4015654 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGCATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT159637 WP_002886901.1 NZ_CP054403:c4565320-4565078 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT159637 NZ_CP070098:4015819-4015873 [Escherichia coli]
CAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References