Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 683282..684114 Replicon chromosome
Accession NZ_CP054353
Organism Escherichia coli strain SCU-172

Toxin (Protein)


Gene name yeeV Uniprot ID A7ZVJ9
Locus tag HPE50_RS03220 Protein ID WP_000854765.1
Coordinates 683740..684114 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag HPE50_RS03215 Protein ID WP_001295723.1
Coordinates 683282..683650 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPE50_RS03185 680118..680573 + 456 WP_000581504.1 hypothetical protein -
HPE50_RS03190 680652..680885 + 234 WP_001119729.1 DUF905 family protein -
HPE50_RS03195 680985..681803 + 819 WP_174183200.1 DUF945 domain-containing protein -
HPE50_RS03200 681858..682343 + 486 WP_174183201.1 antirestriction protein -
HPE50_RS03205 682359..682835 + 477 WP_001186774.1 RadC family protein -
HPE50_RS03210 682898..683119 + 222 WP_000692345.1 DUF987 domain-containing protein -
HPE50_RS03215 683282..683650 + 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HPE50_RS03220 683740..684114 + 375 WP_000854765.1 TA system toxin CbtA family protein Toxin
HPE50_RS03225 684111..684602 + 492 WP_000976842.1 hypothetical protein -
HPE50_RS03230 684619..684795 + 177 WP_000839290.1 DUF957 domain-containing protein -
HPE50_RS03235 684713..684903 + 191 Protein_614 hypothetical protein -
HPE50_RS03240 684895..685053 + 159 WP_001467148.1 hypothetical protein -
HPE50_RS03245 685705..688596 + 2892 WP_000580532.1 DEAD/DEAH box helicase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13970.98 Da        Isoelectric Point: 7.2909

>T159435 WP_000854765.1 NZ_CP054353:683740-684114 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRHNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T159435 NZ_CP070046:c325979-325877 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT159435 WP_001295723.1 NZ_CP054353:683282-683650 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT159435 NZ_CP070046:325870-326015 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A7ZVJ9

Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References