Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2483198..2484033 Replicon chromosome
Accession NZ_CP054169
Organism Escherichia coli strain STO_Bone1B

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1U9SHU4
Locus tag HRS04_RS13065 Protein ID WP_000854752.1
Coordinates 2483656..2484033 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID E3PJ72
Locus tag HRS04_RS13060 Protein ID WP_001278232.1
Coordinates 2483198..2483566 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRS04_RS13035 (2480313) 2480313..2480508 + 196 Protein_2351 DUF905 family protein -
HRS04_RS13040 (2480626) 2480626..2481444 + 819 WP_074527539.1 DUF932 domain-containing protein -
HRS04_RS13045 (2481786) 2481786..2482259 + 474 WP_000855059.1 antirestriction protein -
HRS04_RS13050 (2482275) 2482275..2482751 + 477 WP_001186774.1 RadC family protein -
HRS04_RS13055 (2482814) 2482814..2483035 + 222 WP_000692345.1 DUF987 domain-containing protein -
HRS04_RS13060 (2483198) 2483198..2483566 + 369 WP_001278232.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
HRS04_RS13065 (2483656) 2483656..2484033 + 378 WP_000854752.1 TA system toxin CbtA family protein Toxin
HRS04_RS13070 (2484030) 2484030..2484179 + 150 Protein_2358 DUF5983 family protein -
HRS04_RS13075 (2484279) 2484279..2484359 + 81 Protein_2359 hypothetical protein -
HRS04_RS13080 (2485175) 2485175..2485546 + 372 WP_001295631.1 IS110 family transposase -
HRS04_RS13085 (2485817) 2485817..2486182 + 366 WP_223350516.1 EutP/PduV family microcompartment system protein -
HRS04_RS13090 (2486283) 2486283..2486612 - 330 WP_000450409.1 DUF496 family protein -
HRS04_RS13095 (2486784) 2486784..2487842 - 1059 WP_001200892.1 FUSC family protein -
HRS04_RS13100 (2488040) 2488040..2488513 - 474 WP_001105384.1 DNA gyrase inhibitor SbmC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14076.08 Da        Isoelectric Point: 8.2905

>T158875 WP_000854752.1 NZ_CP054169:2483656-2484033 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T158875 NZ_CP069873:c1284497-1284150 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCGATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13491.37 Da        Isoelectric Point: 6.6290

>AT158875 WP_001278232.1 NZ_CP054169:2483198-2483566 [Escherichia coli]
VSDALSGTMLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT158875 NZ_CP069873:c1284150-1283851 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCAGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1U9SHU4

Antitoxin

Source ID Structure
AlphaFold DB E3PJ72

References