Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2415936..2416512 Replicon chromosome
Accession NZ_CP054139
Organism Mucilaginibacter mali strain G2-14

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag HQ865_RS10190 Protein ID WP_173414803.1
Coordinates 2415936..2416217 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HQ865_RS10195 Protein ID WP_173414804.1
Coordinates 2416219..2416512 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HQ865_RS10170 2411840..2412199 - 360 WP_173414799.1 hypothetical protein -
HQ865_RS10175 2412207..2413052 - 846 WP_173414800.1 formate dehydrogenase accessory sulfurtransferase FdhD -
HQ865_RS10180 2413286..2413786 - 501 WP_173414801.1 peptidylprolyl isomerase -
HQ865_RS10185 2413820..2415823 - 2004 WP_173414802.1 thioredoxin domain-containing protein -
HQ865_RS10190 2415936..2416217 + 282 WP_173414803.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HQ865_RS10195 2416219..2416512 + 294 WP_173414804.1 HigA family addiction module antidote protein Antitoxin
HQ865_RS10200 2416602..2418572 + 1971 WP_173414805.1 M1 family metallopeptidase -
HQ865_RS10205 2418662..2419057 + 396 WP_202020466.1 hypothetical protein -
HQ865_RS10210 2419159..2421441 + 2283 WP_173414806.1 UvrD-helicase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(19-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(5-79)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10961.60 Da        Isoelectric Point: 10.2523

>T158768 WP_173414803.1 NZ_CP054139:2415936-2416217 [Mucilaginibacter mali]
MITSFGSKDTEKIWNGVRVVKLPIEIQTIGRRKLRMINNSQNIQDLTIPPSNKLEKKKGDLKDYYSIRINDQWRIIFKWN
NGNASDVEIIDYH

Download         Length: 282 bp

>T158768 NZ_CP069812:166445-166741 [Cupriavidus oxalaticus]
ATGGAGAAGGGGACGGCGCATTACCCGCTGTGGCGGGTGCGGGAGTTGATTGCTGGCGGGTTGGTCAACTTGACTACATC
GGCCTTTGAGGGTGCGAGAAACATGTCACTTACTCGCGCCGACGTGCTCGACGTAGTGGCTGGACTGCAACCGGCTGACT
TCTACAAGAGCATGACGACCTACACCGACCATACCGTTTGGCAGGATGTATATCGGCCGAGTACGCCGTATGGGTCAATT
TATCTCAAGCTGACGGTTGTTGAAAAAGTCCTGATCGTGTCCTTCAAGGCCCGCTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11117.77 Da        Isoelectric Point: 6.4692

>AT158768 WP_173414804.1 NZ_CP054139:2416219-2416512 [Mucilaginibacter mali]
MEKLPNIHPGEILSEEFLIPLNITAYRLAKETKIPQTRVSEIIKGNRRITADTALRLSKFFGNSAKFWLGLQDDFDLENE
LNQNNEVLQLIKQHVAA

Download         Length: 294 bp

>AT158768 NZ_CP069812:166768-167169 [Cupriavidus oxalaticus]
ATGCAATGCCCAGTCTGCGGTGGCGCCAAGCTCGAGAGGCGCCGTAAGGATTTCGTATACACATACCGGGGTGAGTCCAC
AGTTTTCGAAGCCGTGCTTGCCGATTGGTGCCCGAAGTGCGGGGAAGGAGTCCTGGATGCGGAAGAAGAAGAGCGGATCG
GGCCACTTGCGCTTGCGTTCAACAAACAGGTCAATGCGTCGCTGATAGACCCGGCGTACATTACCGGGGTACGCAAGAAA
CTTCGCCTGGACCAGCGCGAGGCGGCCGAGATCTTTGGCGGCGGCGTCAATGCATTCTCGCGCTACGAGACGGGCAAAAC
CAAACCCCCGCTCGCGCTGGTCAAGCTGTTGAAACTGCTCGACCGCCACCCGGAACTGCTCGAAGAAGTCCGGGCGGCCT
GA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References