Detailed information of TA system TA158709

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 2528839..2529494
• Replicon: chromosome
• Accession: NZ_CP054106
• Organism: Bordetella pertussis strain NZ24

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: HRJ78_RS12195
• Protein ID: WP_047122780.1
• Coordinates: 2529243..2529494 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: Q7VY40
• Locus tag: HRJ78_RS12190
• Protein ID: WP_003809516.1
• Coordinates: 2528839..2529240 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HRJ78_RS12160 (HRJ78_12165)	2524022..2525044	-	1023	WP_003809532.1	amino acid ABC transporter substrate-binding protein	-
HRJ78_RS12165 (HRJ78_12170)	2525181..2526218	-	1038	WP_023853543.1	L-threonylcarbamoyladenylate synthase	-
HRJ78_RS12170 (HRJ78_12175)	2526238..2527428	-	1191	WP_010930406.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
HRJ78_RS12175 (HRJ78_12180)	2527431..2527946	-	516	WP_019247930.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
HRJ78_RS12180 (HRJ78_12185)	2528096..2528575	-	480	WP_010930405.1	disulfide bond formation protein B	-
HRJ78_RS12185 (HRJ78_12190)	2528583..2528819	-	237	WP_010930404.1	DUF5993 family protein	-
HRJ78_RS12190 (HRJ78_12195)	2528839..2529240	-	402	WP_003809516.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
HRJ78_RS12195 (HRJ78_12200)	2529243..2529494	-	252	WP_047122780.1	type II toxin-antitoxin system MqsR family toxin	Toxin
HRJ78_RS12200 (HRJ78_12205)	2529549..2530430	-	882	WP_003809513.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
HRJ78_RS12205 (HRJ78_12210)	2530655..2531101	+	447	WP_003819827.1	GFA family protein	-
HRJ78_RS12210 (HRJ78_12215)	2531186..2532250	-	1065	WP_003809510.1	fructose-bisphosphate aldolase class II	-
HRJ78_RS12215 (HRJ78_12220)	2532387..2532968	-	582	WP_019247931.1	MOSC domain-containing protein	-
HRJ78_RS12220 (HRJ78_12225)	2533203..2534333	+	1131	WP_010930401.1	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (10-82)

Antitoxin

• Antitoxin MqsA/HigA-2 (1-131)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 8952.52 Da
• Isoelectric Point: 9.7242

>T158709 WP_047122780.1 NZ_CP054106:c2529494-2529243 [Bordetella pertussis]
IGGAATKKPGQKRRAGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAVYLKLTVLDGVPIVSF
KEL

Nucleotide

• Length: 252 bp

>T158709 NZ_CP069713:c127564-127406 [Escherichia coli]
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14528.70 Da
• Isoelectric Point: 8.5005

>AT158709 WP_003809516.1 NZ_CP054106:c2529240-2528839 [Bordetella pertussis]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Nucleotide

• Length: 402 bp

>AT158709 NZ_CP069713:c127832-127608 [Escherichia coli]
TCACACAGATTACCCGTAAACAGCCTGAATGAGCGGGTTATTTTCAGGAAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT

Structures

Antitoxin

• AlphaFold DB: A0A0H3LKS6