Detailed information of TA system TA158679

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 2527795..2528450
• Replicon: chromosome
• Accession: NZ_CP054076
• Organism: Bordetella pertussis strain NZ55

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: HRK10_RS12260
• Protein ID: WP_047122780.1
• Coordinates: 2528199..2528450 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: Q7VY40
• Locus tag: HRK10_RS12255
• Protein ID: WP_003809516.1
• Coordinates: 2527795..2528196 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HRK10_RS12225 (HRK10_12160)	2522978..2524000	-	1023	WP_003809532.1	amino acid ABC transporter substrate-binding protein	-
HRK10_RS12230 (HRK10_12165)	2524137..2525174	-	1038	WP_023853543.1	L-threonylcarbamoyladenylate synthase	-
HRK10_RS12235 (HRK10_12170)	2525194..2526384	-	1191	WP_010930406.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
HRK10_RS12240 (HRK10_12175)	2526387..2526902	-	516	WP_019247930.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
HRK10_RS12245 (HRK10_12180)	2527052..2527531	-	480	WP_010930405.1	disulfide bond formation protein B	-
HRK10_RS12250 (HRK10_12185)	2527539..2527775	-	237	WP_010930404.1	DUF5993 family protein	-
HRK10_RS12255 (HRK10_12190)	2527795..2528196	-	402	WP_003809516.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
HRK10_RS12260 (HRK10_12195)	2528199..2528450	-	252	WP_047122780.1	type II toxin-antitoxin system MqsR family toxin	Toxin
HRK10_RS12265 (HRK10_12200)	2528505..2529386	-	882	WP_003809513.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
HRK10_RS12270 (HRK10_12205)	2529611..2530057	+	447	WP_003819827.1	GFA family protein	-
HRK10_RS12275 (HRK10_12210)	2530142..2531206	-	1065	WP_003809510.1	fructose-bisphosphate aldolase class II	-
HRK10_RS12280 (HRK10_12215)	2531343..2531924	-	582	WP_019247931.1	MOSC domain-containing protein	-
HRK10_RS12285 (HRK10_12220)	2532159..2533289	+	1131	WP_010930401.1	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (10-82)

Antitoxin

• Antitoxin MqsA/HigA-2 (1-131)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 8952.52 Da
• Isoelectric Point: 9.7242

>T158679 WP_047122780.1 NZ_CP054076:c2528450-2528199 [Bordetella pertussis]
IGGAATKKPGQKRRAGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAVYLKLTVLDGVPIVSF
KEL

Nucleotide

• Length: 252 bp

>T158679 NZ_CP069710:c2118096-2117689 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCGCAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14528.70 Da
• Isoelectric Point: 8.5005

>AT158679 WP_003809516.1 NZ_CP054076:c2528196-2527795 [Bordetella pertussis]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Nucleotide

• Length: 402 bp

>AT158679 NZ_CP069710:c2118343-2118077 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTATGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3LKS6