Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 2529879..2530534 Replicon chromosome
Accession NZ_CP054070
Organism Bordetella pertussis strain NZ61

Toxin (Protein)


Gene name mqsR Uniprot ID -
Locus tag HRK15_RS12210 Protein ID WP_047122780.1
Coordinates 2530283..2530534 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID Q7VY40
Locus tag HRK15_RS12205 Protein ID WP_003809516.1
Coordinates 2529879..2530280 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRK15_RS12175 (HRK15_12170) 2525062..2526084 - 1023 WP_003809532.1 amino acid ABC transporter substrate-binding protein -
HRK15_RS12180 (HRK15_12175) 2526221..2527258 - 1038 WP_023853543.1 L-threonylcarbamoyladenylate synthase -
HRK15_RS12185 (HRK15_12180) 2527278..2528468 - 1191 WP_010930406.1 5-(carboxyamino)imidazole ribonucleotide synthase -
HRK15_RS12190 (HRK15_12185) 2528471..2528986 - 516 WP_019247930.1 5-(carboxyamino)imidazole ribonucleotide mutase -
HRK15_RS12195 (HRK15_12190) 2529136..2529615 - 480 WP_010930405.1 disulfide bond formation protein B -
HRK15_RS12200 (HRK15_12195) 2529623..2529859 - 237 WP_010930404.1 DUF5993 family protein -
HRK15_RS12205 (HRK15_12200) 2529879..2530280 - 402 WP_003809516.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
HRK15_RS12210 (HRK15_12205) 2530283..2530534 - 252 WP_047122780.1 type II toxin-antitoxin system MqsR family toxin Toxin
HRK15_RS12215 (HRK15_12210) 2530589..2531470 - 882 WP_003809513.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
HRK15_RS12220 (HRK15_12215) 2531695..2532141 + 447 WP_003819827.1 GFA family protein -
HRK15_RS12225 (HRK15_12220) 2532226..2533290 - 1065 WP_003809510.1 fructose-bisphosphate aldolase class II -
HRK15_RS12230 (HRK15_12225) 2533427..2534008 - 582 WP_019247931.1 MOSC domain-containing protein -
HRK15_RS12235 (HRK15_12230) 2534243..2535373 + 1131 WP_010930401.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(10-82)

Antitoxin

Antitoxin MqsA/HigA-2

(1-131)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 8952.52 Da        Isoelectric Point: 9.7242

>T158664 WP_047122780.1 NZ_CP054070:c2530534-2530283 [Bordetella pertussis]
IGGAATKKPGQKRRAGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAVYLKLTVLDGVPIVSF
KEL

Download         Length: 252 bp

>T158664 NZ_CP069709:2592326-2592433 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14528.70 Da        Isoelectric Point: 8.5005

>AT158664 WP_003809516.1 NZ_CP054070:c2530280-2529879 [Bordetella pertussis]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Download         Length: 402 bp

>AT158664 NZ_CP069709:c2592279-2592213 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3LKS6

References