Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 1652155..1652636 Replicon chromosome
Accession NZ_CP054067
Organism Bordetella pertussis strain NZ64

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HRK18_RS08020 Protein ID WP_225975616.1
Coordinates 1652457..1652636 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HRK18_RS08015 Protein ID WP_019247905.1
Coordinates 1652155..1652454 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRK18_RS08005 (HRK18_07970) 1648263..1648937 - 675 WP_010930489.1 response regulator transcription factor -
HRK18_RS08010 (HRK18_07975) 1649067..1652141 + 3075 WP_023995112.1 autotransporter SphB2 -
HRK18_RS08015 (HRK18_07980) 1652155..1652454 - 300 WP_019247905.1 NadS family protein Antitoxin
HRK18_RS08020 (HRK18_07985) 1652457..1652636 - 180 WP_225975616.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HRK18_RS08025 (HRK18_07990) 1652769..1653392 - 624 WP_010930492.1 glutathione S-transferase N-terminal domain-containing protein -
HRK18_RS08030 (HRK18_07995) 1653636..1654505 + 870 WP_010930493.1 TauD/TfdA family dioxygenase -
HRK18_RS08035 (HRK18_08000) 1654483..1655427 - 945 WP_010930494.1 LysR family transcriptional regulator -
HRK18_RS08040 (HRK18_08005) 1655513..1656535 - 1023 WP_023852774.1 tripartite tricarboxylate transporter substrate binding protein -
HRK18_RS08045 (HRK18_08010) 1656552..1657325 - 774 WP_010930496.1 SDR family NAD(P)-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(5-58)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-96)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6859.09 Da        Isoelectric Point: 10.2010

>T158662 WP_225975616.1 NZ_CP054067:c1652636-1652457 [Bordetella pertussis]
IRKMHYGRQGTGKRGGIRVIYYWISQDCQIYMLAAYAKSKKINLTPDEIAALRELVKEL

Download         Length: 180 bp

>T158662 NZ_CP069709:2211914-2212201 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10978.76 Da        Isoelectric Point: 11.2467

>AT158662 WP_019247905.1 NZ_CP054067:c1652454-1652155 [Bordetella pertussis]
MKKDNTVFNDLQASLKQAVAIRQGKMPPSRVFKVETVDVKATREKTHMSQTEFAKAIHVSVRTLQNWEQGHRNPTGPAMA
LLKIVASAPDIAVRALRTA

Download         Length: 300 bp

>AT158662 NZ_CP069709:2211675-2211914 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References