Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 613283..613902 Replicon chromosome
Accession NZ_CP054048
Organism Yersinia massiliensis strain 2011N-4075

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag HRD68_RS03945 Protein ID WP_002208622.1
Coordinates 613699..613902 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A0T9UMX9
Locus tag HRD68_RS03940 Protein ID WP_019212878.1
Coordinates 613283..613651 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRD68_RS03910 608985..609245 + 261 WP_050082629.1 type B 50S ribosomal protein L31 -
HRD68_RS03915 609261..609404 + 144 WP_002208618.1 type B 50S ribosomal protein L36 -
HRD68_RS03920 609487..610365 - 879 WP_108088009.1 metal ABC transporter substrate-binding protein -
HRD68_RS03925 610394..611251 - 858 WP_050082626.1 metal ABC transporter permease -
HRD68_RS03930 611248..611985 - 738 WP_057644342.1 ABC transporter ATP-binding protein -
HRD68_RS03935 612771..613124 + 354 WP_050286524.1 hypothetical protein -
HRD68_RS03940 613283..613651 + 369 WP_019212878.1 Hha toxicity modulator TomB Antitoxin
HRD68_RS03945 613699..613902 + 204 WP_002208622.1 expression modulating protein YmoA Toxin
HRD68_RS03950 614615..617125 - 2511 WP_108088297.1 autotransporter outer membrane beta-barrel domain-containing protein -
HRD68_RS03955 617814..618236 + 423 WP_050082618.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T158566 WP_002208622.1 NZ_CP054048:613699-613902 [Yersinia massiliensis]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

>T158566 NZ_CP069677:c2121298-2121191 [Escherichia coli O126:H45]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14204.96 Da        Isoelectric Point: 4.4314

>AT158566 WP_019212878.1 NZ_CP054048:613283-613651 [Yersinia massiliensis]
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWVNDPTAAVNLQLNDLIEHIASFVMSFKIKYPDDGDLSELVEEYL
DDTYTLFSSYGINDPELRRWQKTKERLFRLFSGEYICTLMKS

Download         Length: 369 bp

>AT158566 NZ_CP069677:2121345-2121411 [Escherichia coli O126:H45]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2K5S

Antitoxin

Source ID Structure
AlphaFold DB A0A0T9UMX9

References