Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 860288..860946 Replicon chromosome
Accession NZ_CP053928
Organism Nocardioides sp. WS12

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HRC28_RS03890 Protein ID WP_182378876.1
Coordinates 860288..860677 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HRC28_RS03895 Protein ID WP_182378877.1
Coordinates 860674..860946 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRC28_RS03865 855909..856283 - 375 WP_182378871.1 hypothetical protein -
HRC28_RS03870 856286..857014 - 729 WP_182378872.1 LytTR family DNA-binding domain-containing protein -
HRC28_RS03875 857011..858153 - 1143 WP_182378873.1 histidine kinase -
HRC28_RS03880 858166..859332 - 1167 WP_182378874.1 hypothetical protein -
HRC28_RS03885 859342..860238 - 897 WP_182378875.1 class I SAM-dependent methyltransferase -
HRC28_RS03890 860288..860677 - 390 WP_182378876.1 type II toxin-antitoxin system VapC family toxin Toxin
HRC28_RS03895 860674..860946 - 273 WP_182378877.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
HRC28_RS03900 861020..861748 + 729 WP_182378878.1 oxidoreductase -
HRC28_RS03905 862043..862852 - 810 WP_182378879.1 HAD-IB family hydrolase -
HRC28_RS03910 862983..864095 + 1113 WP_182378880.1 septum site determining protein -
HRC28_RS03915 864095..865264 + 1170 WP_182378881.1 TadA family conjugal transfer-associated ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13484.34 Da        Isoelectric Point: 5.1130

>T158327 WP_182378876.1 NZ_CP053928:c860677-860288 [Nocardioides sp. WS12]
MIVDASAVLAVLFAEPEAESFKNLMSSTACQMSTANWLEAVMRAEGSRGPTGGAELDTIVTGLGIGLVAVTEAHARAARI
AFRRYGRGSGSPAKLNFGDCFAYALSAASGEPLLFKGDDFTHTDVLRAL

Download         Length: 390 bp

>T158327 NZ_CP069624:c106344-105022 [Escherichia coli]
ATGCCTAAACTAGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCTGAGTGGTTAGCCAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCTAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGATAGCGTTGGTGCCGTGACGTTAATCCCCGAAGA
TGAAACCGTAACGTGTCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGTTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACTGCGCTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAGGGAATAACGCCAACGACGCACATTATCAAATTGCCGATTGGCGAAAT
CAGACAGCCCAATGCGACGCTCGATCTTAGCCAAAGCGTTGATAATGAGTATTACTGTTTGCTGCTGGCGAAAGAACTCG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAGGGTGCGCGCGTTAGCGGTCAAACGTTTTGACAGGCGTTGG
AATACTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGCCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCCGGTATCGCGCAAATTATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAGTTTCAGGTCTTCCAGTGGTTGATTGGCGCAACAGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGGCTCACACCATTTTATGACATCATTTCGGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTCTGGCGACAGCAAAGGTGCTGAAATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGAATTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCACGGTCGGTTAAGCCGAGAATACGGTATTAAGTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9864.13 Da        Isoelectric Point: 4.8182

>AT158327 WP_182378877.1 NZ_CP053928:c860946-860674 [Nocardioides sp. WS12]
MSLNIKNERVHALAREAARVTGKTQTSAIEEALVKLLAEYGVDPAEADRQRRLDIVHQAQIRFAALPEATGPDRILSDDD
LYDPVTGLPA

Download         Length: 273 bp

>AT158327 NZ_CP069624:c106610-106344 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAACGGCTGGAC
GCAGAGCGAGTTGGCGAAAAAAATCGGCATTAAGCAGGCGACAATTTCCAATTTCGAAAACAATCCTGACAATACCTCGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAAGCA
GCAGAACAGCAAGATTTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References