Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 5018792..5019528 Replicon chromosome
Accession NZ_CP053927
Organism Serratia marcescens strain 11/2010

Toxin (Protein)


Gene name vapC Uniprot ID A0A5C7DEM5
Locus tag HP437_RS24990 Protein ID WP_015379310.1
Coordinates 5019049..5019528 (+) Length 160 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A5C7DAD3
Locus tag HP437_RS24985 Protein ID WP_015379309.1
Coordinates 5018792..5019052 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HP437_RS24965 5014863..5015543 + 681 WP_180547892.1 GMP/IMP nucleotidase -
HP437_RS24970 5015540..5015947 + 408 WP_015379306.1 ribosome-associated heat shock protein Hsp15 -
HP437_RS24975 5015973..5016851 + 879 WP_015379307.1 Hsp33 family molecular chaperone HslO -
HP437_RS24980 5017046..5018665 + 1620 WP_015379308.1 phosphoenolpyruvate carboxykinase (ATP) -
HP437_RS24985 5018792..5019052 + 261 WP_015379309.1 plasmid stability-like protein Antitoxin
HP437_RS24990 5019049..5019528 + 480 WP_015379310.1 type II toxin-antitoxin system VapC family toxin Toxin
HP437_RS24995 5019563..5020933 - 1371 WP_038881686.1 two-component system sensor histidine kinase EnvZ -
HP437_RS25000 5020930..5021649 - 720 WP_004709363.1 two-component system response regulator OmpR -
HP437_RS25005 5021907..5022212 - 306 WP_049202813.1 chaperone-modulator protein CbpM -
HP437_RS25010 5022218..5023180 - 963 WP_070913842.1 curved DNA-binding protein -
HP437_RS25015 5023411..5023884 + 474 WP_180547893.1 transcription elongation factor GreB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 160 a.a.        Molecular weight: 17998.63 Da        Isoelectric Point: 5.9070

>T158325 WP_015379310.1 NZ_CP053927:5019049-5019528 [Serratia marcescens]
MIVLDTNVVSELLRPAPHYNVLRWLDEQDTYRFYLSAIVVAELYTGIACMPHGKKQLELQTNLGDMLQEEFSDRILPFDV
GCAMQHAELMGANRRRGIGVSMPDTQIAATCLHYGAALATRNTKDFLHCGIELIDPWQAPTGRRLHEDAAEYYVMSRKS

Download         Length: 480 bp

>T158325 NZ_CP069622:1791-2075 [Escherichia coli]
ATGAGCTATAACCTTGAATTTGATCCCCGAGCCCTGAAGGAATGGCGCAAGCTCGGGGATGATGTCCGTCTGCAGTTCAA
GAAAAAACTCGAGCAGGTTCTACAACACCCGCGGATCGATAAAAATCGCCTGCGAGAGCTGCATGACTGCTACAAAATCA
AGCTCCGTGCATCCGGTTATCGCTTGGTCTATCAGGTTCGCGATCAAACCATTACGGTATTCGTGGTGGCGGTCGGTAAG
CGCGAGCGTTCTGCCGCTTACGATGCGGCCGATAAACGCTTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9907.29 Da        Isoelectric Point: 5.1898

>AT158325 WP_015379309.1 NZ_CP053927:5018792-5019052 [Serratia marcescens]
MATITVRNLDDEIKELLRISAAKNGHSMEEEARMILKQALVKKPPRYGLGTRMHQYFAEFGGVELEIPPRDEAPHRIVNF
DEDDEK

Download         Length: 261 bp

>AT158325 NZ_CP069622:1559-1801 [Escherichia coli]
ATGGCCACGATTAATATTCGGATCGATGACGAGCTGAAAAGCCGCTCTTATGCCGCACTGGAAAAGCTGGGCGTAACGCC
GTCCGAGGTTCTGCGCCAAACACTGGAATATGTGGCCCAAAGCGGACGTTTGCCGTTCCAGCAGGTTTTGCTGACCGAGG
ATGATGCCGATTTGATGGCTATCGTTCGGGATCGTCTGGAAAACCCACAGGCGGGCGTAAAGGTGTCACTGGATGAGCTA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5C7DEM5

Antitoxin

Source ID Structure
AlphaFold DB A0A5C7DAD3

References