Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4468796..4469408 Replicon chromosome
Accession NZ_CP053927
Organism Serratia marcescens strain 11/2010

Toxin (Protein)


Gene name hicA Uniprot ID D2TUP9
Locus tag HP437_RS22230 Protein ID WP_012906750.1
Coordinates 4468796..4468975 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A2F0PUM3
Locus tag HP437_RS22235 Protein ID WP_055312958.1
Coordinates 4468998..4469408 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HP437_RS22210 4464541..4465464 - 924 WP_033649631.1 glutaminase B -
HP437_RS22215 4465762..4466850 + 1089 WP_180547708.1 site-specific integrase -
HP437_RS22220 4467063..4467278 + 216 WP_180547709.1 hypothetical protein -
HP437_RS22225 4467299..4468195 + 897 WP_180547710.1 S49 family peptidase -
HP437_RS22230 4468796..4468975 + 180 WP_012906750.1 type II toxin-antitoxin system HicA family toxin Toxin
HP437_RS22235 4468998..4469408 + 411 WP_055312958.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HP437_RS22240 4469463..4470581 + 1119 WP_180547711.1 acyltransferase -
HP437_RS22245 4470556..4470972 - 417 WP_180547712.1 tail fiber assembly protein -
HP437_RS22250 4470985..4472706 - 1722 WP_180547713.1 hypothetical protein -
HP437_RS22255 4472693..4473349 - 657 WP_180547714.1 DUF2612 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4465762..4509219 43457


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6644.85 Da        Isoelectric Point: 10.9132

>T158324 WP_012906750.1 NZ_CP053927:4468796-4468975 [Serratia marcescens]
MDSRNAIAMIEADGWYLVRVKGSHHQFKHPTKKGLVTVKHPQKDIPLPTLKSIKKQAGL

Download         Length: 180 bp

>T158324 NZ_CP069621:c4881536-4881429 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCGTGATTTTCTGGCACGACCTGGCAGCACCGATCCTTGCGGGAATTATTACCGCAGCGAT
TGTTGGCTGGTGGCGTAGCCGGAAGTAA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14889.72 Da        Isoelectric Point: 4.2855

>AT158324 WP_055312958.1 NZ_CP053927:4468998-4469408 [Serratia marcescens]
MLYPVAIDKGDSSFGVRVPDIPGCFSGGDNYQDAIESAREAIEAHIELLVEDGEAVPEGTNVETWLSDPDYAGVVWALVD
VDITRLMGKAEKINVTLPSLLIRRIDQFVAAHPEYGSRSGFLSRVAADRVISRENR

Download         Length: 411 bp

>AT158324 NZ_CP069621:4881592-4881653 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTGACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D6XDK4

Antitoxin

Source ID Structure
AlphaFold DB A0A2F0PUM3

References