Detailed information of TA system TA158323

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 4303834..4304503
• Replicon: chromosome
• Accession: NZ_CP053927
• Organism: Serratia marcescens strain 11/2010

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: HP437_RS21445
• Protein ID: WP_060422869.1
• Coordinates: 4303834..4304256 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A8B4GS04
• Locus tag: HP437_RS21450
• Protein ID: WP_019455657.1
• Coordinates: 4304237..4304503 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HP437_RS21425	4299724..4300242	+	519	WP_038871234.1	flavodoxin FldB	-
HP437_RS21430	4300279..4301643	-	1365	WP_049277063.1	cell envelope integrity protein CreD	-
HP437_RS21435	4301724..4303142	-	1419	WP_180547661.1	two-component system sensor histidine kinase CreC	-
HP437_RS21440	4303139..4303834	-	696	WP_049277068.1	two-component system response regulator CreB	-
HP437_RS21445	4303834..4304256	-	423	WP_060422869.1	protein YgfX	Toxin
HP437_RS21450	4304237..4304503	-	267	WP_019455657.1	FAD assembly factor SdhE	Antitoxin
HP437_RS21455	4304824..4305816	+	993	WP_049199219.1	tRNA-modifying protein YgfZ	-
HP437_RS21460	4305855..4306352	-	498	WP_060422863.1	DUF2165 domain-containing protein	-
HP437_RS21465	4306503..4307177	-	675	WP_038871224.1	hemolysin III family protein	-
HP437_RS21470	4307361..4307969	+	609	WP_060422860.1	HD domain-containing protein	-
HP437_RS21475	4308002..4308928	-	927	WP_038871218.1	ribokinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16438.50 Da
• Isoelectric Point: 10.8114

>T158323 WP_060422869.1 NZ_CP053927:c4304256-4303834 [Serratia marcescens]
VAQWRCDIRISWRTQLFSLLTHGVLILLILISPWPEGLGPLWLVLLTLVVFQCIRSQKRIAAVQGELRLLADRRFSWHGR
EWRLAKKPWMPGYGMLLTLQPTEGKKRRRLWLASDCMSKEEWRHLRQLLLYPPAGDGEEA

Nucleotide

• Length: 423 bp

>T158323 NZ_CP069621:4685016-4685396 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGTCCCGTCGCAGTTAATCAACAGCATCGATATTCTCCGGGCCCGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATGACATTACCCTGGGCAGGCATCCGGAGGAGGCGAAACAATGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10417.91 Da
• Isoelectric Point: 4.7921

>AT158323 WP_019455657.1 NZ_CP053927:c4304503-4304237 [Serratia marcescens]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLNDADKALFIRLLECDDPDLFNWLMNHGAPQDSELQRMVTLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT158323 NZ_CP069621:4684595-4684969 [Escherichia coli]
GTGTCAGACACGCTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCAGT
TCAGCGACGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Structures

Antitoxin

• AlphaFold DB: A0A8B4GS04