Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4638923..4639449 Replicon chromosome
Accession NZ_CP053925
Organism Serratia marcescens strain 12/2010

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag HP475_RS22640 Protein ID WP_000323025.1
Coordinates 4638923..4639210 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID J5W3H0
Locus tag HP475_RS22645 Protein ID WP_004196370.1
Coordinates 4639210..4639449 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HP475_RS22625 4634534..4636510 - 1977 WP_033649617.1 biosynthetic arginine decarboxylase -
HP475_RS22630 4637419..4638573 + 1155 WP_049235236.1 methionine adenosyltransferase -
HP475_RS22635 4638697..4638849 - 153 WP_049301666.1 Hok/Gef family protein -
HP475_RS22640 4638923..4639210 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
HP475_RS22645 4639210..4639449 - 240 WP_004196370.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
HP475_RS22650 4639700..4640065 + 366 WP_009651956.1 hypothetical protein -
HP475_RS22655 4640109..4640846 + 738 WP_008460272.1 HupE/UreJ family protein -
HP475_RS22660 4640860..4641549 + 690 WP_004196322.1 hypothetical protein -
HP475_RS22665 4641580..4642956 - 1377 WP_004196363.1 chromate efflux transporter -
HP475_RS22670 4642913..4643890 - 978 WP_004196334.1 chromate resistance protein -
HP475_RS22675 4643920..4644112 + 193 Protein_4429 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4631740..4653179 21439


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T158304 WP_000323025.1 NZ_CP053925:c4639210-4638923 [Serratia marcescens]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T158304 NZ_CP069621:c68761-68483 [Escherichia coli]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCATGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ATCCGTTAAGCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGTAACTGGCGAATCACATTTGAATTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9018.43 Da        Isoelectric Point: 4.3894

>AT158304 WP_004196370.1 NZ_CP053925:c4639449-4639210 [Serratia marcescens]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLCNPKPVRVTLDEL

Download         Length: 240 bp

>AT158304 NZ_CP069621:c68483-68199 [Escherichia coli]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTTAATGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCTACGGCAAGTCGATTGCTGACCGGAAAAGCAGCTTTGACGCCAGAAATGGCAA
TAAAACTGTCTGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCAGAA
AAAACAGTGGATGTGTCGCGACTGCGCCGTCTGGTTACGCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4QRH4

References