Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4126147..4126803 Replicon chromosome
Accession NZ_CP053925
Organism Serratia marcescens strain 12/2010

Toxin (Protein)


Gene name vapC Uniprot ID A0A2V4G0W2
Locus tag HP475_RS20140 Protein ID WP_041036282.1
Coordinates 4126147..4126536 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8G2LCA8
Locus tag HP475_RS20145 Protein ID WP_004941563.1
Coordinates 4126540..4126803 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HP475_RS20125 4122614..4124044 + 1431 WP_049213353.1 multidrug transporter subunit MdtD -
HP475_RS20130 4124041..4125423 + 1383 WP_033635541.1 two-component system sensor histidine kinase BaeS -
HP475_RS20135 4125423..4126139 + 717 WP_033635542.1 two-component system response regulator BaeR -
HP475_RS20140 4126147..4126536 - 390 WP_041036282.1 type II toxin-antitoxin system VapC family toxin Toxin
HP475_RS20145 4126540..4126803 - 264 WP_004941563.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
HP475_RS20150 4127143..4127481 + 339 WP_033648841.1 YegP family protein -
HP475_RS20155 4127662..4129014 + 1353 WP_033635545.1 tRNA 5-hydroxyuridine modification protein YegQ -
HP475_RS20160 4129481..4130386 + 906 WP_049234947.1 lipid kinase YegS -
HP475_RS20165 4130676..4131725 + 1050 WP_033635553.1 class I fructose-bisphosphate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14309.56 Da        Isoelectric Point: 7.8786

>T158301 WP_041036282.1 NZ_CP053925:c4126536-4126147 [Serratia marcescens]
MYMFDTNTVSHLFRQHPQVLNVMEKLPPSAVCISSVTEAELLYGVAKRRNKALQSMVEAFLAAVTVYAWDSEAARCYGEM
RANMEKKGKIMGALDQLIAAHAQSRGATLVTNDRAFAMVPGLAVEDWTR

Download         Length: 390 bp

>T158301 NZ_CP069605:c2266757-2266677 [Dickeya dianthicola]
AATGCCAACTTTTAGCGCACGGCTCTCTCCAAAGAGCCATTTCCCTAGACCGGGCACAGGAATCGTGTTCGGTCTTTTTT
T

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10062.31 Da        Isoelectric Point: 4.6702

>AT158301 WP_004941563.1 NZ_CP053925:c4126803-4126540 [Serratia marcescens]
MERIAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLSIIAQTPVPQEFLGAEDRQQGVADR
DPFSEEE

Download         Length: 264 bp

>AT158301 NZ_CP069605:2266675-2266757 [Dickeya dianthicola]
ATAAAAAAAGACCGAACACGATTCCTGTGCCCGGTCTAGGGAAATGGCTCTTTGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2V4G0W2

Antitoxin

Source ID Structure

References