Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1095856..1096477 Replicon chromosome
Accession NZ_CP053925
Organism Serratia marcescens strain 12/2010

Toxin (Protein)


Gene name Hha Uniprot ID A0A8B4G7F9
Locus tag HP475_RS05175 Protein ID WP_004940313.1
Coordinates 1095856..1096059 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A2X2G5J9
Locus tag HP475_RS05180 Protein ID WP_004940312.1
Coordinates 1096109..1096477 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HP475_RS05150 1091648..1092094 + 447 WP_049235195.1 type II secretion system protein M -
HP475_RS05155 1092130..1092945 + 816 WP_049235196.1 A24 family peptidase -
HP475_RS05160 1092942..1093304 - 363 WP_033647278.1 type II secretion system pilot lipoprotein GspS -
HP475_RS05165 1093558..1094988 + 1431 WP_033637339.1 N-acetylglucosamine-binding protein GbpA -
HP475_RS05170 1095041..1095559 + 519 WP_049235197.1 cytochrome b/b6 domain-containing protein -
HP475_RS05175 1095856..1096059 - 204 WP_004940313.1 hemolysin expression modulator Hha Toxin
HP475_RS05180 1096109..1096477 - 369 WP_004940312.1 Hha toxicity modulator TomB Antitoxin
HP475_RS05185 1096636..1096989 - 354 WP_033653245.1 hypothetical protein -
HP475_RS05190 1097397..1098110 + 714 WP_033647273.1 ABC transporter ATP-binding protein -
HP475_RS05195 1098107..1098964 + 858 WP_033637343.1 metal ABC transporter permease -
HP475_RS05200 1098990..1099868 + 879 WP_041033680.1 metal ABC transporter substrate-binding protein -
HP475_RS05205 1099975..1100115 - 141 WP_004940304.1 type B 50S ribosomal protein L36 -
HP475_RS05210 1100128..1100382 - 255 WP_004940303.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8107.37 Da        Isoelectric Point: 6.9756

>T158289 WP_004940313.1 NZ_CP053925:c1096059-1095856 [Serratia marcescens]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPTSVWKYVR

Download         Length: 204 bp

>T158289 NZ_CP069604:1862994-1863308 [Dickeya dianthicola]
ATGCAATTCACCGTATACGGTAATACCGGGAAAAGCGTCGTTTACCCGCTGTTGCTCGATGTCACGAGCGATATTATTGG
ACAGTTGAATCGTCGGATAGTGATCCCGTTGCTCCCTGTTGAAAAGTACCCGGCAGGCCGCCGGCCGGATCGCCTAGTCC
CTGTCGTCAGGCTGACGGACGGCAAAGAGTACGCCGTAATGACGCACGAGCTGGCAAGTATCCCTGTGCAGGCTCTGGGG
GCGGTGTTTTGTGATGCGTCGCAGTACCGTACTCAGGTAAAGGCCGCAATAGATTTCCTCATTGACGGTATTTAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14261.95 Da        Isoelectric Point: 4.4314

>AT158289 WP_004940312.1 NZ_CP053925:c1096477-1096109 [Serratia marcescens]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEDICTTMKT

Download         Length: 369 bp

>AT158289 NZ_CP069604:1862755-1862991 [Dickeya dianthicola]
ATGACCGCGAAACAGCGCAACACGCAGAGCGTGACCATGACGGTAGAGCGTGCCTTACTGGTCCGGGCGCGTGAGGCGGG
CATTAACCTGAGTGCCACTCTGACAACCGCCCTGGATGCCGAGCTTCGCCGTCATGAAGCGAAAAAATGGCAGGAAGAGA
ACAGGGAAGCCATCGACGCATTAAATCGTTTTCATGATGAGCACGGCTGTTTCAGCGATGAATACCGGACGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4G7F9

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2G5J9

References