Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 14648..15249 Replicon chromosome
Accession NZ_CP053925
Organism Serratia marcescens strain 12/2010

Toxin (Protein)


Gene name vapC Uniprot ID A0A2V4FS51
Locus tag HP475_RS00070 Protein ID WP_033649548.1
Coordinates 14648..15028 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A086G6A0
Locus tag HP475_RS00075 Protein ID WP_004933932.1
Coordinates 15028..15249 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HP475_RS00045 9901..11181 + 1281 WP_047569945.1 DUF3748 domain-containing protein -
HP475_RS00050 11212..11559 - 348 WP_033636538.1 YceK/YidQ family lipoprotein -
HP475_RS00055 11870..12283 + 414 WP_047569943.1 heat shock chaperone IbpA -
HP475_RS00060 12384..12812 + 429 WP_004933922.1 heat shock chaperone IbpB -
HP475_RS00065 12979..14637 + 1659 WP_049235249.1 putative transporter -
HP475_RS00070 14648..15028 - 381 WP_033649548.1 type II toxin-antitoxin system VapC family toxin Toxin
HP475_RS00075 15028..15249 - 222 WP_004933932.1 ribbon-helix-helix domain-containing protein Antitoxin
HP475_RS00080 15324..16574 - 1251 WP_004933935.1 valine--pyruvate transaminase -
HP475_RS00085 16710..18773 - 2064 WP_049235250.1 alpha-amylase -
HP475_RS00090 18970..19122 + 153 WP_019455508.1 hypothetical protein -
HP475_RS00095 19124..20101 - 978 WP_016929588.1 glyoxylate/hydroxypyruvate reductase GhrB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-102)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14171.50 Da        Isoelectric Point: 7.3170

>T158285 WP_033649548.1 NZ_CP053925:c15028-14648 [Serratia marcescens]
MVAQRALFDTNILIDYLNGIPQAKDVLTEYHINPAISAITWMEVMVGAKKQGPALELKTRQFLGQFLLLPITDEVAERAV
ELRHSQHVKLPDAIVWATAQVGFRTLISRNPKDFGTDNGVLMPYRL

Download         Length: 381 bp

>T158285 NZ_CP069604:c1259145-1258942 [Dickeya dianthicola]
ATGAAAAAAATCGACTATTTAATGCGTTTGCGTAAATGCACAACCATCGACACGCTTGAGCGTGTTATAGAAAAAAACAA
GTACGAGCTTTCCAACGATGAGCTTGAAATGTTCTATTCAGCTGCAGACCACCGCCTGGCAGAGCTGACGATGAATAAGC
TTTACGACAAAGTACCGACTGCTGTGTGGAAATACGTTCGTTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8593.53 Da        Isoelectric Point: 4.4791

>AT158285 WP_004933932.1 NZ_CP053925:c15249-15028 [Serratia marcescens]
MTRIVIDLPEEDLRQLDNLKNIRHVPRAEIIRQAVSRYLTENHVEDPSNAFGLWSGAMGDGVDYENRQREEWE

Download         Length: 222 bp

>AT158285 NZ_CP069604:c1259567-1259199 [Dickeya dianthicola]
ATGGATGAGTACACACCTCAACATTATGATATTGCCCAACTCAGATTCTTGTGTGAAAATCTGCACGACGAAAGTATCGC
GACATTAGGTGATAGCAGTCGTAGCTGGGTGAATGACCCGACTTCTGCGGTCAACCTTCAACTAAACGAACTTATCGAGC
ATATTGCGGCATTTGTTGTTACCTACAAAATAAAATACCCGCATGAAGCTGCGTTATGTGAACGGGTTGAGAAATATCTG
GACGACACTTATATTCTTTTCAGTAACTACGGTATAAATGACGCCGAGTTGCAGAAATGGCGAAAATCCAAGTCACAATT
ATTCAGAATGTTCTCAGAAAAGAGCATCTGTACGGTAGTAAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2V4FS51

Antitoxin

Source ID Structure
AlphaFold DB A0A086G6A0

References