Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE-RelB |
| Location | 315125..315684 | Replicon | chromosome |
| Accession | NZ_CP053823 | ||
| Organism | Vibrio cholerae strain E7G | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | D2YI11 |
| Locus tag | HPY10_RS14840 | Protein ID | WP_000578473.1 |
| Coordinates | 315125..315403 (-) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | HPY10_RS14845 | Protein ID | WP_000381186.1 |
| Coordinates | 315400..315684 (-) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HPY10_RS14790 | 310547..310741 | + | 195 | WP_001885060.1 | 50S ribosomal protein L35 | - |
| HPY10_RS14795 | 310783..311136 | + | 354 | WP_001138366.1 | 50S ribosomal protein L20 | - |
| HPY10_RS14800 | 311218..312180 | - | 963 | WP_000841995.1 | integron integrase IntIA | - |
| HPY10_RS14805 | 312582..312735 | + | 154 | Protein_252 | DUF645 family protein | - |
| HPY10_RS14810 | 312976..313146 | + | 171 | WP_001080654.1 | hypothetical protein | - |
| HPY10_RS14815 | 313146..313547 | + | 402 | WP_000351248.1 | type II toxin-antitoxin system death-on-curing family toxin | - |
| HPY10_RS14820 | 313450..313713 | + | 264 | WP_175247629.1 | DUF3265 domain-containing protein | - |
| HPY10_RS14825 | 313688..314053 | + | 366 | WP_069730855.1 | hypothetical protein | - |
| HPY10_RS14830 | 314209..314484 | + | 276 | WP_000436062.1 | hypothetical protein | - |
| HPY10_RS14835 | 314630..314968 | + | 339 | WP_175246331.1 | hypothetical protein | - |
| HPY10_RS14840 | 315125..315403 | - | 279 | WP_000578473.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | Toxin |
| HPY10_RS14845 | 315400..315684 | - | 285 | WP_000381186.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| HPY10_RS14850 | 315893..316168 | + | 276 | WP_000436062.1 | hypothetical protein | - |
| HPY10_RS14855 | 316348..316518 | + | 171 | WP_001080654.1 | hypothetical protein | - |
| HPY10_RS14860 | 316518..316919 | + | 402 | WP_000351248.1 | type II toxin-antitoxin system death-on-curing family toxin | - |
| HPY10_RS14865 | 316906..317055 | + | 150 | WP_175247721.1 | DUF3265 domain-containing protein | - |
| HPY10_RS14870 | 317042..317323 | + | 282 | WP_084981660.1 | DUF1289 domain-containing protein | - |
| HPY10_RS14875 | 317571..318371 | + | 801 | WP_114763308.1 | nucleotide-binding protein | - |
| HPY10_RS14880 | 318362..318478 | + | 117 | WP_114763309.1 | DUF3265 domain-containing protein | - |
| HPY10_RS14885 | 318569..318850 | + | 282 | WP_000086649.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| HPY10_RS14890 | 318847..319134 | + | 288 | WP_000869999.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| HPY10_RS14895 | 319265..319564 | - | 300 | WP_000802134.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| HPY10_RS14900 | 319561..319803 | - | 243 | WP_001107720.1 | type II toxin-antitoxin system ParD family antitoxin | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 310054..527444 | 217390 | |
| - | inside | Integron | - | - | 311218..527444 | 216226 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10868.59 Da Isoelectric Point: 4.6794
>T158073 WP_000578473.1 NZ_CP053823:c315403-315125 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAEKTDELIETKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND
MIFWEEASLNDREKIFEFLYDFNPAAAEKTDELIETKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND
Download Length: 279 bp
>T158073 NZ_CP069561:6372-6659 [Escherichia coli]
ATGAGGTATCAGGTAAAATTCAGGGAAGATGCGCTGAAAGAGTGGCAAAAAATGGACAAGACTATTCAGCAACAGTTTGC
GAAAAAGCTAAAAAAGTGCTGCGACAATCCGCATATTCCTTCCGCAAAACTGCGCGGGATAAAGGACTGCTACAAAATAA
AATTACGTGCGTCAGGTTTTCGCCTGGTCTATCAGGTGATTGACGAACAATTAATTATCGCTGTTGTAGCTGTGGGTAAA
CGTGAGCGCAGTGACGTTTATAATCTTGCCAGTGAAAGAATGAGATAA
ATGAGGTATCAGGTAAAATTCAGGGAAGATGCGCTGAAAGAGTGGCAAAAAATGGACAAGACTATTCAGCAACAGTTTGC
GAAAAAGCTAAAAAAGTGCTGCGACAATCCGCATATTCCTTCCGCAAAACTGCGCGGGATAAAGGACTGCTACAAAATAA
AATTACGTGCGTCAGGTTTTCGCCTGGTCTATCAGGTGATTGACGAACAATTAATTATCGCTGTTGTAGCTGTGGGTAAA
CGTGAGCGCAGTGACGTTTATAATCTTGCCAGTGAAAGAATGAGATAA
Antitoxin
Download Length: 95 a.a. Molecular weight: 10915.28 Da Isoelectric Point: 8.0775
>AT158073 WP_000381186.1 NZ_CP053823:c315684-315400 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFVEHDIAKVR
MAERKAKIRNRGHA
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFVEHDIAKVR
MAERKAKIRNRGHA
Download Length: 285 bp
>AT158073 NZ_CP069561:6124-6375 [Escherichia coli]
ATGCCTAACATTATTCTCAGTGATACAAGCGCCAGTGTCAGCGAGCTGAAGAAAAATCCGATGGCGACAGTCAGCGCCGG
TGATGGTTTCCCGGTCGCTATCCTGAACCGTAATCAGCCTGCTTTCTACTGTGTACCCGCAGAGCTGTACGAAAAGATGC
TCGATGCCCTGGACGATCAGGAGCTGGTTAAACTGGTAGCCGAACGCAGCAACCAACCGCTGCATGATGTAGACCTGGAT
AAATACCTATGA
ATGCCTAACATTATTCTCAGTGATACAAGCGCCAGTGTCAGCGAGCTGAAGAAAAATCCGATGGCGACAGTCAGCGCCGG
TGATGGTTTCCCGGTCGCTATCCTGAACCGTAATCAGCCTGCTTTCTACTGTGTACCCGCAGAGCTGTACGAAAAGATGC
TCGATGCCCTGGACGATCAGGAGCTGGTTAAACTGGTAGCCGAACGCAGCAACCAACCGCTGCATGATGTAGACCTGGAT
AAATACCTATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|