Detailed information of TA system TA158063

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 426939..427486
• Replicon: chromosome
• Accession: NZ_CP053821
• Organism: Vibrio cholerae strain SA10G

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HPY11_RS15830
• Protein ID: WP_071187828.1
• Coordinates: 427184..427486 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HPY11_RS15825
• Protein ID: WP_055031549.1
• Coordinates: 426939..427196 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPY11_RS15780	421985..422992	+	1008	WP_175246433.1	hypothetical protein	-
HPY11_RS15785	423062..423181	+	120	WP_114780049.1	acetyltransferase	-
HPY11_RS15790	423122..423439	-	318	WP_148532547.1	CcdB family protein	-
HPY11_RS15795	423439..423684	-	246	WP_001260801.1	type II toxin-antitoxin system CcdA family antitoxin	-
HPY11_RS15800	424039..424182	+	144	Protein_442	DUF645 family protein	-
HPY11_RS15805	424346..424981	+	636	WP_175246434.1	DUF2807 domain-containing protein	-
HPY11_RS15810	425140..425616	+	477	WP_175246430.1	DM13 domain-containing protein	-
HPY11_RS15815	425778..426203	+	426	WP_061051384.1	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	-
HPY11_RS15820	426362..426748	+	387	WP_123011595.1	NUDIX hydrolase	-
HPY11_RS15825	426939..427196	+	258	WP_055031549.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HPY11_RS15830	427184..427486	+	303	WP_071187828.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HPY11_RS15835	427804..428436	+	633	WP_175246435.1	FRG domain-containing protein	-
HPY11_RS15840	428579..429442	+	864	WP_175246436.1	hypothetical protein	-
HPY11_RS15845	429614..430366	+	753	WP_114720911.1	SDR family oxidoreductase	-
HPY11_RS15850	430643..430816	+	174	WP_175246437.1	DUF3709 domain-containing protein	-
HPY11_RS15855	431148..431996	+	849	WP_175246438.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	catB9	-	310496..487283	176787
	-	inside	Integron	-	-	311660..487283	175623

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11694.60 Da
• Isoelectric Point: 5.8741

>T158063 WP_071187828.1 NZ_CP053821:427184-427486 [Vibrio cholerae]
MAEIVWTEPALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRIPPELKHLNYREVVVNPCRVFYKYDDANV
RILFVMRAERDLRRLMLTKQ

Nucleotide

• Length: 303 bp

>T158063 NZ_CP069559:c4422491-4422177 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9619.14 Da
• Isoelectric Point: 7.3176

>AT158063 WP_055031549.1 NZ_CP053821:426939-427196 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDKM
SKWLK

Nucleotide

• Length: 258 bp

>AT158063 NZ_CP069559:c4422727-4422494 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG