Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 433620..434160 Replicon chromosome
Accession NZ_CP053814
Organism Vibrio cholerae strain W7G

Toxin (Protein)


Gene name relE Uniprot ID A0A151JGK8
Locus tag HPY09_RS15765 Protein ID WP_000277238.1
Coordinates 433620..433889 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KML3
Locus tag HPY09_RS15770 Protein ID WP_001258569.1
Coordinates 433882..434160 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY09_RS15715 428906..429589 + 684 WP_001010781.1 hypothetical protein -
HPY09_RS15720 429728..430501 + 774 WP_175247187.1 NERD domain-containing protein -
HPY09_RS15725 430794..430976 + 183 Protein_448 DUF645 family protein -
HPY09_RS15730 431161..431451 - 291 WP_000221352.1 type II toxin-antitoxin system RelE/ParE family toxin -
HPY09_RS15735 431441..431689 - 249 WP_000213182.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
HPY09_RS15740 431928..432380 + 453 WP_020196891.1 hypothetical protein -
HPY09_RS15745 432377..432487 + 111 WP_175247337.1 DUF3265 domain-containing protein -
HPY09_RS15750 432468..432830 + 363 WP_175247338.1 DUF4144 domain-containing protein -
HPY09_RS15755 432936..433097 + 162 Protein_454 DUF3709 domain-containing protein -
HPY09_RS15760 433118..433351 + 234 WP_142737015.1 DUF3709 domain-containing protein -
HPY09_RS15765 433620..433889 - 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin Toxin
HPY09_RS15770 433882..434160 - 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HPY09_RS15775 434318..434971 + 654 WP_175247339.1 hypothetical protein -
HPY09_RS15780 435062..435222 + 161 Protein_459 DUF3709 domain-containing protein -
HPY09_RS15785 435243..435476 + 234 WP_175247188.1 DUF3709 domain-containing protein -
HPY09_RS15790 435903..435992 + 90 WP_141239104.1 DUF645 family protein -
HPY09_RS15795 435995..436084 + 90 Protein_462 DUF645 family protein -
HPY09_RS15800 436280..437836 + 1557 WP_175247189.1 GIY-YIG nuclease family protein -
HPY09_RS15805 438032..438892 + 861 WP_175247340.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 317876..527757 209881


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10406.11 Da        Isoelectric Point: 9.5084

>T158020 WP_000277238.1 NZ_CP053814:c433889-433620 [Vibrio cholerae]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF

Download         Length: 270 bp

>T158020 NZ_CP069542:c4250798-4250400 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10088.58 Da        Isoelectric Point: 6.0728

>AT158020 WP_001258569.1 NZ_CP053814:c434160-433882 [Vibrio cholerae]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV

Download         Length: 279 bp

>AT158020 NZ_CP069542:c4251094-4250801 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A151JGK8

Antitoxin

Source ID Structure
AlphaFold DB A0A151KTP9

References