Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 378453..378981 Replicon chromosome
Accession NZ_CP053801
Organism Vibrio cholerae strain SO5Y

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag HPY15_RS15260 Protein ID WP_000221352.1
Coordinates 378691..378981 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag HPY15_RS15255 Protein ID WP_000213183.1
Coordinates 378453..378701 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY15_RS15210 373697..373966 - 270 WP_001114075.1 DUF4160 domain-containing protein -
HPY15_RS15215 374218..374313 - 96 WP_001907607.1 DUF645 family protein -
HPY15_RS15220 374556..374666 - 111 WP_086017781.1 DUF3265 domain-containing protein -
HPY15_RS15225 375187..375465 + 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
HPY15_RS15230 375458..375727 + 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin -
HPY15_RS15235 376323..376748 - 426 WP_052724878.1 hypothetical protein -
HPY15_RS15240 376895..377593 - 699 WP_046126203.1 HAD family phosphatase -
HPY15_RS15245 377684..378241 - 558 WP_046126204.1 GNAT family N-acetyltransferase -
HPY15_RS15250 378238..378336 - 99 WP_142741450.1 acetyltransferase -
HPY15_RS15255 378453..378701 + 249 WP_000213183.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HPY15_RS15260 378691..378981 + 291 WP_000221352.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HPY15_RS15265 378999..379109 - 111 WP_082798255.1 DUF3265 domain-containing protein -
HPY15_RS15270 379106..379423 - 318 WP_001232701.1 HigA family addiction module antidote protein -
HPY15_RS15275 379434..379721 - 288 WP_001162670.1 type II toxin-antitoxin system RelE/ParE family toxin -
HPY15_RS15280 380073..380281 - 209 Protein_374 DUF3709 domain-containing protein -
HPY15_RS15285 380578..381210 - 633 WP_175235993.1 hypothetical protein -
HPY15_RS15290 381464..381745 - 282 WP_080341684.1 DUF1289 domain-containing protein -
HPY15_RS15295 381694..381807 - 114 WP_080341690.1 acetyltransferase -
HPY15_RS15300 381863..382243 - 381 WP_046126206.1 glyoxalase -
HPY15_RS15305 382712..383632 - 921 WP_001896359.1 IS5-like element ISVch8 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 296008..431802 135794
- inside Integron - - 370413..382391 11978
- inside Integron - - 382712..427017 44305
- flank IS/Tn - - 382712..383632 920


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T157904 WP_000221352.1 NZ_CP053801:378691-378981 [Vibrio cholerae]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T157904 NZ_CP069504:361777-362166 [Acinetobacter pittii]
TTGATAAAAGAATTAAATTTTGAGCTGAAATATAGCCGTGTCTCGGTAATATTTCAGCTTTTTGTTGGTTTGGGTTTAGC
AATCCTGCTTTATCAATTATTAACACCGATATGGTGGCTATGTGCTGTCATTCTTCTATTTATTGGTTTTATTTTCTTTC
TAAAGCAAGCACAAATATCTCAAATTGAATATTTAGATCAAAAATTATGGTCGATTGCATATTTTTCGAAAAAAGAAATT
TACCGTGGGGAAATTACTAAAATAATTGATTATCAGTTATTTGTAGTTATTTATTTTGAAGAAACTCCTACGAATATAGC
TATTGTTTGGTTCGATCAGCTTCCTATTCAGCAGTGGAAAAGATTAAAAGTTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT157904 WP_000213183.1 NZ_CP053801:378453-378701 [Vibrio cholerae]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT157904 NZ_CP069504:361513-361770 [Acinetobacter pittii]
ATGTCTGACGAAATGACCTTGGAAGAACGTAAAGTAATTTATCGAGCACGCCGTGGCTTAAAAGAAATTGACGTCTATTT
TGACCCGTATGTAAAAAATTATTATTTAAAAGCTGATCCAGCAGAAAAAGCATTATTTGCAGAGCTAGTTGATCAAGAAG
ATCCAGATTTATTAGATTGGTTCATGGAAGTTTCTGAGCCTCCACGTACTGAGTTACGTGAATTTATTTATAAACTAAAA
CAGTATGTGCATGGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H9L4R3

Antitoxin

Source ID Structure
AlphaFold DB A0A366A3W8

References