Detailed information of TA system TA157855

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): abiEi-abiEii/AbiEii-AbiEi
• Location: 1227636..1229068
• Replicon: chromosome
• Accession: NZ_CP053792
• Organism: Streptococcus canis strain HL_77_1

Toxin (Protein)

• Gene name: abiEi
• Uniprot ID: -
• Locus tag: GE021_RS06165
• Protein ID: WP_164406803.1
• Coordinates: 1228223..1229068 (+)
• Length: 282 a.a.

Antitoxin (Protein)

• Gene name: abiEii
• Uniprot ID: -
• Locus tag: GE021_RS06160
• Protein ID: WP_164406798.1
• Coordinates: 1227636..1228226 (+)
• Length: 197 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GE021_RS06160	1227636..1228226	+	591	WP_164406798.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
GE021_RS06165	1228223..1229068	+	846	WP_164406803.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
GE021_RS06170	1229131..1231932	-	2802	WP_164406818.1	CHAP domain-containing protein	-
GE021_RS06175	1231934..1232953	-	1020	WP_164406907.1	type IV secretion system protein VirB4	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	tet(O)	-	1145052..1271513	126461

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (33-258)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (6-50)

Sequences

Toxin

Protein

• Length: 282 a.a.
• Molecular weight: 32441.04 Da
• Isoelectric Point: 4.9404

>T157855 WP_164406803.1 NZ_CP053792:1228223-1229068 [Streptococcus canis]
MNKAKLTALCHKISKNTGLTFNSVMTYYFLEVILKKLSQSSYSNHYIFKGGFLLSNVIGVESRSTVDIDFLFHQMTLSED
TVEQQLKEILADSEEGISFVIQSITAIKESDDYGGYRATILCQLENIKQVIHLDIATGDAVTPQPITYDYKAIFDEDNFP
IIAYTIETILAEKLQTIYSRNFLNSRSKDFYDVYILSKLKKEDIDFIQLKNACQRTFSYRETELDFEKIIELLERFKSDT
IQNKQWQNYSKKYSYTKGISLADVLDEMIRLIAVLISINSD

Nucleotide

• Length: 846 bp

>T157855 NZ_CP069498:107552-107854 [Acinetobacter pittii]
ATGTACTCAATATATACCACAGAAGCCTTTGATGATTGGTTTACCAAGTTAAAAGATCAACAGGCAAAAAGACGCATACA
AGTCCGAATTGATCGGGTTGAAGATGGGAACTTTGGAGATACTGAACCAGTCGGTGAAGGTGTTTCTGAGTTACGTTTCT
TCTTTGGACCTGGCTATAGGATTTATTACTGCAAGCAAGGGCAAAGGGTCGTTATTCTCTTAGCAGGCGGAGATAAGTCT
ACGCAAAGTAAAGATATAAAACTTGCCCTACAATTAGCACAAGATTTAGAGGAGGAGCTGTAA

Antitoxin

Protein

• Length: 197 a.a.
• Molecular weight: 23245.81 Da
• Isoelectric Point: 8.3458

>AT157855 WP_164406798.1 NZ_CP053792:1227636-1228226 [Streptococcus canis]
MSKKEILLEFIENHNGIITYKDCKALNIPTIYLTRLEKEGILYRVEKGIFLTQNGDYDEYYFFQYRYPKAVFSYISALYL
QQFTDEIPQYFDVTIPRGYRFNTPPANLNIHSVSKENSELGITLVKTPMGNEVRVYDFERIICDFVIHREKIDTELFVKT
LQHYGNYPKKNLTKLYKYATKMNTLDKVKQTLEVLV

Nucleotide

• Length: 591 bp

>AT157855 NZ_CP069498:107855-108136 [Acinetobacter pittii]
ATGGCTATCAAACTTCGTAAATGGGATAGTGCTGAGCATCTTAAAACAGAAGAAGATATGCAAGCTTACCTACAAGCCTG
TATCGATGAATCTAATGGTGATGCTGCATTCATTGCTAAAGCTTTAGGTAACATTGCTAAAGCTAAAGGAATGGCTCAAT
TATCACGAGATACAGGTCTAGGCCGAGAAAGTCTTTACAAAGCACTTTCTGGTGATGTTAACCCTAGTTTTGATACTGTG
ATTAAAGTTGTAAAAGCACTGAATTTACGCTTAGCAATTTAA