Detailed information of TA system TA157347

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 1322761..1323327
• Replicon: chromosome
• Accession: NZ_CP053655
• Organism: Bifidobacterium breve strain 1101A

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HPH06_RS05825
• Protein ID: WP_106629487.1
• Coordinates: 1323034..1323327 (+)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0L7AY16
• Locus tag: HPH06_RS05820
• Protein ID: WP_025262989.1
• Coordinates: 1322761..1323030 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPH06_RS05795 (HPH06_05710)	1318510..1319196	-	687	WP_013140734.1	response regulator transcription factor	-
HPH06_RS05800 (HPH06_05715)	1319328..1319846	+	519	WP_258900499.1	hypothetical protein	-
HPH06_RS05805 (HPH06_05720)	1319843..1320733	+	891	WP_003831809.1	hypothetical protein	-
HPH06_RS05810 (HPH06_05725)	1320730..1321410	+	681	WP_003829413.1	ABC transporter ATP-binding protein	-
HPH06_RS05815 (HPH06_05730)	1321416..1322576	+	1161	WP_258900956.1	ABC transporter permease	-
HPH06_RS05820 (HPH06_05735)	1322761..1323030	+	270	WP_025262989.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HPH06_RS05825 (HPH06_05740)	1323034..1323327	+	294	WP_106629487.1	type II toxin-antitoxin system YafQ family toxin	Toxin
HPH06_RS05830 (HPH06_05745)	1323384..1323611	+	228	WP_232781923.1	hypothetical protein	-
HPH06_RS05835	1323593..1324177	+	585	WP_258900500.1	MFS transporter	-
HPH06_RS05840	1324228..1324512	+	285	WP_258900501.1	transporter	-
HPH06_RS05845 (HPH06_05755)	1324841..1326421	+	1581	WP_258900502.1	amino acid permease	-
HPH06_RS05850 (HPH06_05760)	1326664..1326903	-	240	WP_003829454.1	hypothetical protein	-
HPH06_RS05855 (HPH06_05765)	1327199..1327552	+	354	WP_014483707.1	DUF488 domain-containing protein	-
HPH06_RS05860 (HPH06_05770)	1327618..1328046	-	429	WP_258900503.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-94)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (3-87)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11207.96 Da
• Isoelectric Point: 10.1999

>T157347 WP_106629487.1 NZ_CP053655:1323034-1323327 [Bifidobacterium breve]
MLKPDYTAAFQRDIKKLKRRHADLRPLKEVIRLVLEDTADSKEALRRRHRAHTLTGDLNGVLECRIGNAGDWLLLWIRDD
GTAMFMRTGSHDELLGK

Nucleotide

• Length: 294 bp

>T157347 NZ_CP069171:31066-31377 [Klebsiella pneumoniae]
ATGCACGTAATTTCAAAAGAGCCTTTTGAGGAAGCGGCAAAGCGATATCCCAACGATTCGTTAGCCATTCGGGCGTTGTA
CCGCTTAGTGCGCGAGACGGACTTCTCTTCTCCAGCTGAGATGCTAACTCTGATACCGAGCCTGGATAATTTTAAGTACA
GGAATAAGTGGTGGGTTTTGGATGTAGGGGGCAACAACTTAAGGGTTATCGCCTATATCAATTTCGTAAATAAGCGCTTC
TACGTGAAGCACATCGCAACCCACGCTGATTACGACAAGTTGACCCGCTATTACAGGGAGAACAAAGAATGA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9860.12 Da
• Isoelectric Point: 4.5742

>AT157347 WP_025262989.1 NZ_CP053655:1322761-1323030 [Bifidobacterium breve]
VSMASVTVRVDADTKQKAANIAEDLGLDLSSVTRAFYKQIVRERRIPLNLSYTTVPPETMEALDEAKNRLADGQPRFNSA
DEMFDSLGI

Nucleotide

• Length: 270 bp

>AT157347 NZ_CP069171:31374-31793 [Klebsiella pneumoniae]
ATGATTACCGACACTGCAAAAGCCATTGAAGCAACCAAACAACTCGTAGCTGCCGTCCCCTTCCTAGGGGGCAGTTCTTC
CGAGAGCGATTACCGCGAAGCGATGGAGCTGGTGGATTATCTGATCGAGAACGACGACGAGAACCCACTTATTGACTTCC
TGGCGAGTAAGATTGCCGACTATGAAGATAACAGCCCTCGTTTCGCTGAGTTCAACAAAGCTATTGCTGAAATACCAGTC
GGCGTTGCACTTCTGCGAACCCTGATTGACCAGCACAAGCTGTCTTATTCAGACCTTAAGGATGAGATCGGATCTAAATC
ATTGGTCAGCCAAATCCTGTCAGGGCAGCGCTCTTTGACCATCACTCACATAAAAGCTCTTTCCGCGCGCTTCGGTGTAA
AACCTGAGTGGTTCCTATAA

Structures

Antitoxin

• AlphaFold DB: A0A0L7AY16