Detailed information of TA system TA157310

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 550807..551386
• Replicon: chromosome
• Accession: NZ_CP053640
• Organism: Staphylococcus aureus strain 14505

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: HA033_RS03095
• Protein ID: WP_001025401.1
• Coordinates: 550807..551052 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	551021..551386 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HA033_RS03045	547058..547672	+	615	WP_000191466.1	hypothetical protein	-
HA033_RS03050	547669..547815	-	147	WP_001794606.1	hypothetical protein	-
HA033_RS03055	547851..548033	-	183	WP_000705240.1	hypothetical protein	-
HA033_RS03060	548103..548834	-	732	WP_000511090.1	XRE family transcriptional regulator	-
HA033_RS03065	548986..549198	+	213	WP_000213811.1	helix-turn-helix transcriptional regulator	-
HA033_RS03070	549246..549689	+	444	WP_000435357.1	hypothetical protein	-
HA033_RS03075	549704..549853	+	150	WP_000771849.1	hypothetical protein	-
HA033_RS03080	549894..550106	-	213	WP_000362644.1	hypothetical protein	-
HA033_RS03085	550176..550373	+	198	WP_031898325.1	hypothetical protein	-
HA033_RS03090	550360..550740	-	381	WP_000773059.1	DUF2513 domain-containing protein	-
HA033_RS03095	550807..551052	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
HA033_RS03100	551021..551386	-	366	WP_001128433.1	hypothetical protein	Antitoxin
HA033_RS03105	551441..551656	+	216	WP_001097552.1	hypothetical protein	-
HA033_RS03110	551681..551944	+	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
HA033_RS03115	551957..552118	+	162	WP_001285954.1	DUF1270 domain-containing protein	-
HA033_RS03120	552197..552520	+	324	WP_000174998.1	hypothetical protein	-
HA033_RS03125	552535..552897	+	363	WP_000985971.1	hypothetical protein	-
HA033_RS03130	552894..554060	+	1167	WP_000762538.1	DUF2800 domain-containing protein	-
HA033_RS03135	554086..554643	+	558	WP_000645045.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T157310 WP_001025401.1 NZ_CP053640:550807-551052 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T157310 NZ_CP069133:c2904450-2904115 [Escherichia coli BW25113]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT157310 NZ_CP053640:c551386-551021 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin