Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ralRA/-
Location 1400234..1400605 Replicon chromosome
Accession NZ_CP053600
Organism Escherichia coli strain Nico21(DE3)

Toxin (Protein)


Gene name ralR Uniprot ID F4VC37
Locus tag HO398_RS06915 Protein ID WP_001317028.1
Coordinates 1400411..1400605 (-) Length 65 a.a.

Antitoxin (RNA)


Gene name ralA
Locus tag -
Coordinates 1400234..1400412 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HO398_RS06890 1396189..1397562 + 1374 WP_000123737.1 ATP-dependent RNA helicase DbpA -
HO398_RS06895 1397691..1398626 - 936 WP_001157407.1 tRNA 2-thiocytidine(32) synthetase TtcA -
HO398_RS06900 1398678..1399913 - 1236 WP_000040858.1 site-specific integrase -
HO398_RS06905 1399915..1400130 - 216 WP_000079604.1 excisionase XisR -
HO398_RS06910 1400209..1400418 - 210 WP_000276809.1 double-strand break reduction protein RcbA -
- 1400234..1400412 + 179 NuclAT_0 - Antitoxin
- 1400234..1400412 + 179 NuclAT_0 - Antitoxin
- 1400234..1400412 + 179 NuclAT_0 - Antitoxin
- 1400234..1400412 + 179 NuclAT_0 - Antitoxin
HO398_RS06915 1400411..1400605 - 195 WP_001317028.1 type I toxin-antitoxin system endodeoxyribonuclease toxin RalR Toxin
HO398_RS06920 1400662..1401471 - 810 WP_000166319.1 recombination protein RecT -
HO398_RS06925 1401464..1402563 - 1100 Protein_1353 PD-(D/E)XK nuclease-like domain-containing protein -
HO398_RS06930 1402665..1402940 - 276 WP_000632297.1 protein RacC -
HO398_RS06935 1403015..1403185 - 171 WP_001352098.1 conserved protein, Rac prophage -
HO398_RS06940 1403185..1403406 - 222 WP_000560223.1 killing protein KilR -
HO398_RS06945 1403848..1404336 + 489 WP_001312793.1 superinfection exclusion protein B -
HO398_RS06950 1404333..1404488 - 156 WP_001169151.1 YdaF family protein -
HO398_RS06955 1404632..1404844 + 213 WP_012775985.1 phage lysis protein EssD -
HO398_RS06960 1404849..1405193 + 345 WP_000193293.1 YdfR family protein -
HO398_RS06965 1405159..1405431 - 273 WP_000370546.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1398678..1410743 12065


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endodeoxyribonuclease toxin RalR

(6-54)


Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 7018.89 Da        Isoelectric Point: 8.9538

>T156977 WP_001317028.1 NZ_CP053600:c1400605-1400411 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Download         Length: 195 bp

>T156977 NZ_CP069074:c1394189-1393896 [Mycobacterium tuberculosis]
GTGAGCGACGACCATCCCTACCACGTGGCGATCACCGCGACAGCGGCACGCGACCTGCAACGCTTACCCGAAAAGATCGC
CGCCGCATGTGTCGAGTTTGTTTTCGGACCGCTGCTTAACAACCCGCATAGGTTGGGCAAGCCGCTGCGCAATGACCTTG
AAGGCCTCCACTCAGCCCGCCGCGGTGATTACCGCGTCGTCTACGCCATCGACGACGGCCACCACCGAGTCGAGATCATC
CACATCGCTCGTCGCAGTGCCAGCTACCGAATGAACCCGTGCCGGCCACGTTAA

Antitoxin


Download         Length: 179 bp

>AT156977 NZ_CP053600:1400234-1400412 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7L6LHV7

Antitoxin

Download structure file

References