Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 562550..563170 Replicon chromosome
Accession NZ_CP053417
Organism Salmonella bongori strain 92-0238

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag CBX32_RS02595 Protein ID WP_001280991.1
Coordinates 562952..563170 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag CBX32_RS02590 Protein ID WP_000344807.1
Coordinates 562550..562924 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CBX32_RS02580 557689..558882 + 1194 WP_020842830.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
CBX32_RS02585 558905..562054 + 3150 WP_001132513.1 multidrug efflux RND transporter permease subunit -
CBX32_RS02590 562550..562924 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
CBX32_RS02595 562952..563170 + 219 WP_001280991.1 hemolysin expression modulator Hha Toxin
CBX32_RS02600 563349..563900 + 552 WP_171922312.1 maltose O-acetyltransferase -
CBX32_RS02605 564018..564488 + 471 WP_079772190.1 YlaC family protein -
CBX32_RS02610 564541..564681 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
CBX32_RS02615 564687..564947 - 261 WP_000801419.1 type B 50S ribosomal protein L31 -
CBX32_RS02620 565152..566702 + 1551 WP_020842828.1 EAL domain-containing protein -
CBX32_RS02630 566941..567330 + 390 WP_000908589.1 MGMT family protein -
CBX32_RS02635 567363..567932 - 570 WP_000779806.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T156784 WP_001280991.1 NZ_CP053417:562952-563170 [Salmonella bongori]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T156784 NZ_CP069071:677542-677949 [Mycobacterium tuberculosis]
GTGATCATCGACACGAGTGCGCTGCTTGCCTATTTCGACGCCGCCGAGCCAGACCACGCCGCAGTGTCTGAGTGCATCGA
TAGCTCCGCAGACGCGCTCGTCGTATCCCCTTATGTGGTAGCGGAACTCGACTATCTCGTCGCCACCCGGGTAGGTGTCG
ATGCCGAGCTCGCCGTCCTGCGTGAACTCGCCGGCGGGGCCTGGGAGCTCGCCAACTGCGGTGCCGCCGAAATCGAGCAG
GCCGCCCGCATCGTCACGAAATACCAGGATCAGCGGATCGGGATCGCGGATGCGGCCAACGTCGTGCTGGCCGACCGATA
CCGCACGCGCACGATCCTCACCCTGGACCGTCGGCACTTCTCGGCGCTGCGGCCGATCGGCGGTGGGCGCTTCACCGTCA
TTCCGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT156784 WP_000344807.1 NZ_CP053417:562550-562924 [Salmonella bongori]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT156784 NZ_CP069071:677330-677545 [Mycobacterium tuberculosis]
GTGGACAAGACGACGGTCTACCTGCCGGATGAACTCAAGGCGGCCGTGAAGCGCGCCGCTCGGCAGCGCGGAGTCTCCGA
AGCGCAGGTAATCCGGGAGTCCATCCGGGCGGCGGTCGGCGGCGCCAAGCCGCCGCCGCGCGGGGGTCTATATGCGGGTT
CGGAGCCCATCGCGCGGCGAGTCGACGAGCTGCTGGCTGGCTTCGGTGAGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References