Detailed information of TA system TA156711

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 3397175..3398922
• Replicon: chromosome
• Accession: NZ_CP053371
• Organism: Proteus terrae subsp. cibarius strain G32

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: HND96_RS15825
• Protein ID: WP_098941872.1
• Coordinates: 3397175..3398548 (+)
• Length: 458 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: HND96_RS15830
• Protein ID: WP_098941871.1
• Coordinates: 3398545..3398922 (+)
• Length: 126 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HND96_RS15810	3392846..3393829	-	984	WP_075673449.1	ABC transporter permease	-
HND96_RS15815	3393814..3395397	-	1584	WP_099659717.1	ABC transporter substrate-binding protein	-
HND96_RS15820	3395803..3396792	-	990	WP_159363578.1	glycosyltransferase	-
HND96_RS15825	3397175..3398548	+	1374	WP_098941872.1	type II toxin-antitoxin system HipA family toxin	Toxin
HND96_RS15830	3398545..3398922	+	378	WP_098941871.1	helix-turn-helix domain-containing protein	Antitoxin
HND96_RS15835	3399044..3399544	-	501	WP_159363579.1	hydrogenase maturation peptidase HycI	-
HND96_RS15840	3399541..3399951	-	411	WP_088494545.1	formate hydrogenlyase maturation HycH family protein	-
HND96_RS15845	3399944..3400726	-	783	WP_072069032.1	NADH-quinone oxidoreductase subunit B family protein	-
HND96_RS15850	3400723..3401277	-	555	WP_075673442.1	hydrogenase 4 subunit H	-
HND96_RS15855	3401289..3403022	-	1734	WP_075673441.1	hydrogenase large subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (174-418)

Antitoxin

• Cro/C1-type helix-turn-helix domain (48-103)

Sequences

Toxin

Protein

• Length: 458 a.a.
• Molecular weight: 52589.44 Da
• Isoelectric Point: 4.6415

>T156711 WP_098941872.1 NZ_CP053371:3397175-3398548 [Proteus terrae subsp. cibarius]
MEKITLQAFLNQEWVDIAIINFPKYDRMLYASKYDITYPITELEYETSYSIEHLYQDDQHAVSINHPVELYFDDSGSPGW
LKFLDDIVPSGASRRYWLQYLDIAELSTEQQNYELLHHGTISPIGNLRVKESLPAPSPLNRNLFFTINDVKNRASDFLDY
AQRKGAAAGGATGAGGEAPKLLLRCNDNEEVWIDTYQDDISNLDKYYLVKFPRGSRSVVDCNILRTEYHFYHELTDMGFD
TIPIKDMRLEEGDNYPSLWLPRFDIKIENNKIIRLAMESVYSILNKAPGTTLYHETVIKELIDKINQSNMVTEFGFQFNT
ANFIIEWVRRDLLNIIFGNSDNHGRNTSLIRYNNAIYLAPIYDFAPMKADPEGIARTTKWGSHSEIGGEYNFINIADSLS
DLIAPEQLLNALQETAQQLLTLKERLEMRGVPTQILTMPSFGFDFIPNKLERWGLLP

Nucleotide

• Length: 1374 bp

>T156711 NZ_CP069069:c3149618-3149226 [Mycobacterium tuberculosis]
ATGACGACGGTGCTGCTCGACTCGCATGTGGCCTACTGGTGGTCGGCCGAGCCGCAGCGTCTCAGCATGGCGGCGAGCCA
GGCCATCGAACACGCCGACGAGCTCGCCGTCGCCGCGATTTCGTGGTTCGAGCTGGCTTGGCTTGCCGAACAGGAACGCA
TCCAACTGGCGATTCCGGTGCTGTCCTGGCTTCAGCAGCTGGCCGAGCACGTTCGCACCGTCGGTATCACGCCCTCGGTC
GCCGCCACGGCGGTGGCGCTGCCCTCGTCGTTCCCCGGCGATCCGGCCGACCGGTTGATCTACGCCACCGCGATCGAACA
CGGCTGGCGGCTGGTGACCAAGGACCGGCGGCTACGCAGTCATCGGCACCCACGACCGGTCACCGTCTGGTAG

Antitoxin

Protein

• Length: 126 a.a.
• Molecular weight: 14108.43 Da
• Isoelectric Point: 10.5220

>AT156711 WP_098941871.1 NZ_CP053371:3398545-3398922 [Proteus terrae subsp. cibarius]
MNNVENKNHIDKFPTRASRKHQFVATTDRKQVISKIMAHLLFGEITQGEALKMLRIKVLGLNQDLYAKLINVSRKTLSEI
ENDRGNYSADIINKVFKPFGLKVGLVPSSPHILSSLLKESPPINE

Nucleotide

• Length: 378 bp

>AT156711 NZ_CP069069:c3149830-3149615 [Mycobacterium tuberculosis]
ATGACCGCTACGGAGGTGAAGGCGAAGATCCTCTCCTTGCTTGATGAAGTGGCCCAGGGCGAGGAGATCGAGATCACCAA
ACACGGCCGCACCGTGGCCCGGCTGGTGGCAGCGACGGGGCCGCACGCGCTGAAGGGTCGATTCTCGGGTGTGGCGATGG
CGGCCGTGGATGACGACGAACTCTTCACCACCGGGGTTTCGTGGAACGTTTCATGA