Detailed information of TA system TA156611

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 2434633..2435859
• Replicon: chromosome
• Accession: NZ_CP053301
• Organism: Burkholderia cenocepacia strain K56-2

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: B4EFY1
• Locus tag: K562_RS28195
• Protein ID: WP_006483155.1
• Coordinates: 2435278..2435859 (+)
• Length: 194 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: K562_RS28190
• Protein ID: WP_006483170.1
• Coordinates: 2434633..2435199 (+)
• Length: 189 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K562_RS28165	2430026..2430661	+	636	WP_006483160.1	cysteine hydrolase	-
K562_RS28170	2430687..2431418	-	732	WP_006483157.1	ribonuclease T2	-
K562_RS28175	2431649..2432038	+	390	WP_006483162.1	OsmC family protein	-
K562_RS28180	2432117..2432689	-	573	WP_006483169.1	hypothetical protein	-
K562_RS28185	2432783..2434186	-	1404	WP_006483168.1	hypothetical protein	-
K562_RS28190	2434633..2435199	+	567	WP_006483170.1	helix-turn-helix domain-containing protein	Antitoxin
K562_RS28195	2435278..2435859	+	582	WP_006483155.1	HD domain-containing protein	Toxin
K562_RS28200	2435915..2436643	+	729	WP_006483165.1	class I SAM-dependent methyltransferase	-
K562_RS28205	2436915..2438108	+	1194	WP_006483156.1	efflux RND transporter periplasmic adaptor subunit	-
K562_RS28210	2438111..2440156	+	2046	WP_006483164.1	MacB family efflux pump subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HD domain (16-173)

Antitoxin

• Cro/C1-type helix-turn-helix domain (12-64)

Sequences

Toxin

Protein

• Length: 194 a.a.
• Molecular weight: 21324.94 Da
• Isoelectric Point: 4.9629

>T156611 WP_006483155.1 NZ_CP053301:2435278-2435859 [Burkholderia cenocepacia]
MNPDTIRARLDFLRDAERLKDVLRSGHTSAGRAESTAEHSWRLCLMALVFAEALPGVDTLKLLKLCVVHDLGEALHGDIP
AIEQAAHPDKSVHERDDLLTLTASLDRAARDEIVALWDEYEAAASPEARAAKALDKLETILQHNQGSNPPDFDYAFNLGY
GRRYTDAAPLFSAIREIVDVDTQRRIDAGGQRA

Nucleotide

• Length: 582 bp

>T156611 NZ_CP069068:712993-713394 [Mycobacterium tuberculosis]
GTGACGGTGCTGCTCGACGCCAACGTGCTGATCGCATTGGTGGTCGCCGAGCATGTGCATCATGATGCCGCAGCGGACTG
GCTCATGGCGTCCGACACCGGATTTGCGACCTGCCCGATGACACAAGGAAGCCTGGTTCGATTCCTGGTGCGCTCGGGAC
AGTCCGCGGCGGCGGCTCGGGATGTCGTCAGTGCGGTCCAGTGCACGAGCCGCCACGAATTCTGGCCCGATGCACTCTCT
TTCGCCGGTGTCGAGGTCGCTGGTGTGGTTGGGCACCGGCAGGTGACCGATGCCTACCTTGCCCAGCTCGCGCGAAGCCA
CGACGGGCAGTTGGCGACGCTCGACAGCGGCTTAGCACACCTGCACGGCGACGTCGCGGTACTCATTCCAACGACCACCT
GA

Antitoxin

Protein

• Length: 189 a.a.
• Molecular weight: 20583.56 Da
• Isoelectric Point: 10.7753

>AT156611 WP_006483170.1 NZ_CP053301:2434633-2435199 [Burkholderia cenocepacia]
MPHPPLHPSSLGPQLKRWRALHRVKQSHAAELFRVAQSTISRWEAGLQQMSPAERATAERLLAARLDSAGDHALARLIAG
STGRMHLVCDLTHRLLASSPARAAEFSRPLSTLLGASLWRYATPEIARMEAALDPLGWYDRAGPPSVEFDTGANASRVVP
IRGSLCRWTRMTLSDGSAVRLVETLDAH

Nucleotide

• Length: 567 bp

>AT156611 NZ_CP069068:712769-712996 [Mycobacterium tuberculosis]
GTGCGCACTACCATCGACCTGCCGCAAGACCTGCACAAGCAGGCACTGGCGATTGCCCGGGATACGCACCGCACGTTGAG
TGAAACGGTCGCCGACCTCATGCGACGAGGCCTGGCCGCCAACCGCCCTACCGCGTTGTCCTCAGACCCCAGAACGGGAT
TGCCTTTGGTGAGCGTCGGGACCGTCGTGACCTCCGAGGACGTGCGTTCATTAGAGGACGAGCAGTGA

Structures

Toxin

• AlphaFold DB: B4EFY1