Detailed information of TA system TA156608

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 1302629..1303275
• Replicon: chromosome
• Accession: NZ_CP053301
• Organism: Burkholderia cenocepacia strain K56-2

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: B4EGU9
• Locus tag: K562_RS23185
• Protein ID: WP_006491144.1
• Coordinates: 1302868..1303275 (+)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: B4EGU8
• Locus tag: K562_RS23180
• Protein ID: WP_006491146.1
• Coordinates: 1302629..1302871 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K562_RS23165	1298624..1300030	+	1407	WP_006491136.1	aspartate ammonia-lyase	-
K562_RS23170	1300108..1301613	+	1506	WP_006491141.1	amino acid permease	-
K562_RS23175	1301687..1302370	-	684	WP_006491145.1	phospholipase	-
K562_RS23180	1302629..1302871	+	243	WP_006491146.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
K562_RS23185	1302868..1303275	+	408	WP_006491144.1	type II toxin-antitoxin system VapC family toxin	Toxin
K562_RS23190	1303392..1303619	-	228	WP_006491154.1	hypothetical protein	-
K562_RS23195	1303677..1306052	+	2376	WP_006491138.1	MCP four helix bundle domain-containing protein	-
K562_RS23200	1306075..1306803	+	729	WP_034178465.1	chemotaxis protein	-
K562_RS23205	1306800..1307381	+	582	WP_006486232.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-122)

Antitoxin

• SpoVT-AbrB domain (7-49)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 14822.93 Da
• Isoelectric Point: 6.2165

>T156608 WP_006491144.1 NZ_CP053301:1302868-1303275 [Burkholderia cenocepacia]
MKFLLDTNAVIAILKGEPAILARLHAWHPADFGIPAIVAHALYYGAYKSQRAAANVARVEALQFEVVSFDTEDAQHAGEI
RAHLIAAGTPIGPYDALIAGQARARQLVLVTHNVREFERVPRLQFEDWLAEPSAD

Nucleotide

• Length: 408 bp

>T156608 NZ_CP069068:c697214-696822 [Mycobacterium tuberculosis]
GTGAACGTACGGCGCGCCCTCGCCGACACATCCGTTTTCATTGGCATCGAGGCGACACGATTCGACCCGGACCGGTTTGC
GGGATACGAATGGGGCGTCTCGGTAGTCACACTCGGCGAGCTGCGGCTCGGGGTGTTGCAAGCCTCCGGCCCCGAGGCCG
CCGCACGTCGGCTCTCCACCTACCAGCTTGCGCAACGGTTCGAACCACTAGGCATCGACGAGGCGGTCTCCGAAGCATGG
GCATTACTGGTGTCCAAGCTGCGCGCCGCCAAACTGCGCGTGCCGATCAACGACAGCTGGATTGCGGCCACAGCCGTGGC
GCACGGCATTGCGATCCTGACCCAAGACAACGACTACGCCGCCATGCCCGACGTCGAGGTCATAACGATCTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8849.02 Da
• Isoelectric Point: 5.0197

>AT156608 WP_006491146.1 NZ_CP053301:1302629-1302871 [Burkholderia cenocepacia]
MDTAKLFKHGGSQAVRLPKDFRFDTAEVRIRRHGAAVILEPMPQDWAWLAPLIGPVDADFEAAATTQPSAQERSGLDVFE

Nucleotide

• Length: 243 bp

>AT156608 NZ_CP069068:c697468-697211 [Mycobacterium tuberculosis]
ATGTCTGCTACGATACCCGCTCGCGATCTTCGCAACCACACCGCCGAGGTACTGCGGCGAGTTGCCGCCGGCGAGGAAAT
CGAGGTGCTCAAGGACAATCGCCCCGTAGCGCGCATCGTTCCGCTCAAGCGGCGCCGCCAATGGTTGCCAGCTGCCGAGG
TGATCGGCGAACTGGTGCGCTTGGGCCCCGATACCACCAATCTGGGCGAGGAGCTGCGAGAGACGCTGACGCAAACCACG
GACGATGTGCGGTGGTGA

Structures

Toxin

• AlphaFold DB: B4EGU9

Antitoxin

• AlphaFold DB: B4EGU8