Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 898198..898806 Replicon chromosome
Accession NZ_CP053301
Organism Burkholderia cenocepacia strain K56-2

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag K562_RS21305 Protein ID WP_006490978.1
Coordinates 898501..898806 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag K562_RS21300 Protein ID WP_006490972.1
Coordinates 898198..898497 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K562_RS21275 893431..894702 + 1272 WP_006490988.1 Rieske 2Fe-2S domain-containing protein -
K562_RS21280 894718..895194 + 477 WP_006490977.1 aromatic-ring-hydroxylating dioxygenase subunit beta -
K562_RS21285 895230..895556 + 327 WP_006490973.1 non-heme iron oxygenase ferredoxin subunit -
K562_RS21290 895546..896766 + 1221 WP_006490971.1 FAD-dependent oxidoreductase -
K562_RS21295 896863..898149 + 1287 WP_006490986.1 DUF445 domain-containing protein -
K562_RS21300 898198..898497 - 300 WP_006490972.1 putative addiction module antidote protein Antitoxin
K562_RS21305 898501..898806 - 306 WP_006490978.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K562_RS21310 899195..900835 + 1641 WP_006490980.1 acetolactate synthase large subunit -
K562_RS21315 900864..902297 + 1434 WP_006490987.1 aldehyde dehydrogenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(9-96)

Antitoxin

Uncharacterized protein HI1420

(4-96)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11270.88 Da        Isoelectric Point: 7.2764

>T156607 WP_006490978.1 NZ_CP053301:c898806-898501 [Burkholderia cenocepacia]
MPYSPPAFSIRTTDVFDAWFAGLPDRRIQARIDRLSMGNPGDWKSAGSPVVEMRIDHGPGYRVYDVRRGTIWVILLCGGD
KSAQQADIRAAHAMLAHLDME

Download         Length: 306 bp

>T156607 NZ_CP069068:679904-680311 [Mycobacterium tuberculosis]
GTGATCATCGACACGAGTGCGCTGCTTGCCTATTTCGACGCCGCCGAGCCAGACCACGCCGCAGTGTCTGAGTGCATCGA
TAGCTCCGCAGACGCGCTCGTCGTATCCCCTTATGTGGTAGCGGAACTCGACTATCTCGTCGCCACCCGGGTAGGTGTCG
ATGCCGAGCTCGCCGTCCTGCGTGAACTCGCCGGCGGGGCCTGGGAGCTCGCCAACTGCGGTGCCGCCGAAATCGAGCAG
GCCGCCCGCATCGTCACGAAATACCAGGATCAGCGGATCGGGATCGCGGATGCGGCCAACGTCGTGCTGGCCGACCGATA
CCGCACGCGCACGATCCTCACCCTGGACCGTCGGCACTTCTCGGCGCTGCGGCCGATCGGCGGTGGGCGCTTCACCGTCA
TTCCGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10608.04 Da        Isoelectric Point: 6.4771

>AT156607 WP_006490972.1 NZ_CP053301:c898497-898198 [Burkholderia cenocepacia]
MDKIKTRPWDSAEHLKTEDDMADYFDACLQEAGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGAKAAA

Download         Length: 300 bp

>AT156607 NZ_CP069068:679692-679907 [Mycobacterium tuberculosis]
GTGGACAAGACGACGGTCTACCTGCCGGATGAACTCAAGGCGGCCGTGAAGCGCGCCGCTCGGCAGCGCGGAGTCTCCGA
AGCGCAGGTAATCCGGGAGTCCATCCGGGCGGCGGTCGGCGGCGCCAAGCCGCCGCCGCGCGGGGGTCTATATGCGGGTT
CGGAGCCCATCGCGCGGCGAGTCGACGAGCTGCTGGCTGGCTTCGGTGAGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References