Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/Tad-HTH_37 |
| Location | 2641580..2642207 | Replicon | chromosome |
| Accession | NZ_CP053284 | ||
| Organism | Escherichia coli strain SCU-104 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A0Q3ID11 |
| Locus tag | HHJ22_RS12840 | Protein ID | WP_016232083.1 |
| Coordinates | 2641580..2641909 (+) | Length | 110 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | HHJ22_RS12845 | Protein ID | WP_000147082.1 |
| Coordinates | 2641899..2642207 (+) | Length | 103 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HHJ22_RS12805 | 2638216..2638830 | - | 615 | WP_001241329.1 | hypothetical protein | - |
| HHJ22_RS12810 | 2639065..2639265 | - | 201 | WP_000994506.1 | protein ninH | - |
| HHJ22_RS12815 | 2639262..2639624 | - | 363 | WP_001624518.1 | RusA family crossover junction endodeoxyribonuclease | - |
| HHJ22_RS12820 | 2639621..2639911 | - | 291 | WP_024194163.1 | DUF1364 domain-containing protein | - |
| HHJ22_RS12825 | 2639935..2640126 | - | 192 | WP_001254269.1 | NinE family protein | - |
| HHJ22_RS12830 | 2640123..2640533 | - | 411 | WP_001076830.1 | recombination protein NinB | - |
| HHJ22_RS12835 | 2640588..2641262 | - | 675 | WP_021571289.1 | ORF6N domain-containing protein | - |
| HHJ22_RS12840 | 2641580..2641909 | + | 330 | WP_016232083.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| HHJ22_RS12845 | 2641899..2642207 | + | 309 | WP_000147082.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| HHJ22_RS12850 | 2642262..2642507 | - | 246 | WP_001624507.1 | hypothetical protein | - |
| HHJ22_RS12855 | 2642506..2643180 | + | 675 | WP_032144013.1 | DUF4145 domain-containing protein | - |
| HHJ22_RS12860 | 2643213..2643644 | - | 432 | WP_000196185.1 | DUF977 family protein | - |
| HHJ22_RS12865 | 2643660..2644431 | - | 772 | Protein_2525 | DUF1627 domain-containing protein | - |
| HHJ22_RS12870 | 2644457..2645197 | - | 741 | WP_021571292.1 | ATP-binding protein | - |
| HHJ22_RS12875 | 2645204..2646292 | - | 1089 | WP_168725754.1 | DNA-binding protein | - |
| HHJ22_RS12880 | 2646313..2646531 | - | 219 | WP_000438870.1 | hypothetical protein | - |
| HHJ22_RS12885 | 2646546..2646842 | - | 297 | WP_000084293.1 | hypothetical protein | - |
| HHJ22_RS12890 | 2646959..2647183 | - | 225 | WP_001054988.1 | helix-turn-helix domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 2638830..2657384 | 18554 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 110 a.a. Molecular weight: 12714.71 Da Isoelectric Point: 9.2605
>T156538 WP_016232083.1 NZ_CP053284:2641580-2641909 [Escherichia coli]
INYIIEYYSDEVEAEILSLPETLQARYIRYTEKMRIYGANLGSPHTEAFGDGLFEIRLKGSEGIGRVFYCTLKGKRIIML
HSFVKKTQKTPPAELRKAETRMKEVKHDW
INYIIEYYSDEVEAEILSLPETLQARYIRYTEKMRIYGANLGSPHTEAFGDGLFEIRLKGSEGIGRVFYCTLKGKRIIML
HSFVKKTQKTPPAELRKAETRMKEVKHDW
Download Length: 330 bp
>T156538 NZ_CP069066:c3688303-3687875 [Mycobacterium tuberculosis]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG
Antitoxin
Download Length: 103 a.a. Molecular weight: 11079.81 Da Isoelectric Point: 9.7256
>AT156538 WP_000147082.1 NZ_CP053284:2641899-2642207 [Escherichia coli]
MTGKRTPPTMTHDEMVEKMLSNPAVKAEYDAIADEFALLDEMLAARKEAGLTQAEVAERMGTKATAITRMESNLASGTSG
PSFATLKKFARATGKKLQIRFV
MTGKRTPPTMTHDEMVEKMLSNPAVKAEYDAIADEFALLDEMLAARKEAGLTQAEVAERMGTKATAITRMESNLASGTSG
PSFATLKKFARATGKKLQIRFV
Download Length: 309 bp
>AT156538 NZ_CP069066:c3688549-3688307 [Mycobacterium tuberculosis]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|