Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 766133..766965 Replicon chromosome
Accession NZ_CP053284
Organism Escherichia coli strain SCU-104

Toxin (Protein)


Gene name yeeV Uniprot ID S1PD64
Locus tag HHJ22_RS03640 Protein ID WP_000854753.1
Coordinates 766133..766507 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID E3PJ72
Locus tag HHJ22_RS03645 Protein ID WP_001278232.1
Coordinates 766597..766965 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ22_RS03605 761200..761799 + 600 WP_001255034.1 type II secretion system minor pseudopilin GspJ -
HHJ22_RS03610 761802..762779 + 978 WP_000633209.1 type II secretion system minor pseudopilin GspK -
HHJ22_RS03615 762776..763954 + 1179 WP_000094991.1 type II secretion system protein GspL -
HHJ22_RS03620 763956..764492 + 537 WP_000942785.1 GspM family type II secretion system protein YghD -
HHJ22_RS03625 764773..765342 - 570 WP_001290247.1 DUF4942 domain-containing protein -
HHJ22_RS03630 765439..765636 - 198 WP_000839281.1 DUF957 domain-containing protein -
HHJ22_RS03635 765648..766136 - 489 WP_000777547.1 hypothetical protein -
HHJ22_RS03640 766133..766507 - 375 WP_000854753.1 TA system toxin CbtA family protein Toxin
HHJ22_RS03645 766597..766965 - 369 WP_001278232.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
HHJ22_RS03650 767128..767322 - 195 WP_001219880.1 DUF987 domain-containing protein -
HHJ22_RS03655 767376..767723 - 348 WP_000612591.1 IS66 family insertion sequence element accessory protein TnpB -
HHJ22_RS03660 767720..768100 - 381 WP_001171523.1 IS66 family insertion sequence hypothetical protein -
HHJ22_RS03665 768313..768501 - 189 Protein_719 transposase domain-containing protein -
HHJ22_RS03670 768562..769695 + 1134 WP_016232250.1 IS110 family transposase -
HHJ22_RS03675 769948..771372 - 1425 Protein_721 IS66 family transposase -
HHJ22_RS03680 771403..771753 - 351 WP_087894478.1 IS66 family insertion sequence element accessory protein TnpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - iucA / iucB / iucC / iucD / iutA / sigA 764646..814751 50105


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14005.00 Da        Isoelectric Point: 8.2905

>T156520 WP_000854753.1 NZ_CP053284:c766507-766133 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Download         Length: 375 bp

>T156520 NZ_CP069066:2250875-2251273 [Mycobacterium tuberculosis]
ATGATCGTCGACACCTCGGTCTGGATCGCATATCTCTCCACGTCAGAGTCGTTGGCCAGTCGCTGGCTAGCCGATCGCAT
TGCCGCTGACTCGACGGTGATCGTGCCCGAGGTGGTGATGATGGAGCTGCTGATCGGTAAGACCGATGAGGACACCGCCG
CACTGCGCCGACGGCTCCTGCAGCGATTCGCTATCGAACCGCTGGCCCCGGTCCGCGACGCGGAAGATGCCGCCGCCATT
CACCGGCGCTGTCGTCGCGGCGGCGACACCGTACGCAGCCTGATCGATTGCCAGGTGGCCGCGATGGCGTTGCGGATCGG
GGTCGCCGTGGCGCATCGTGATCGCGACTACGAGGCGATCCGCACACATTGCGGACTACGCACCGAGCCGTTGTTCTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13491.37 Da        Isoelectric Point: 6.6290

>AT156520 WP_001278232.1 NZ_CP053284:c766965-766597 [Escherichia coli]
VSDALSGTMLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT156520 NZ_CP069066:2250647-2250874 [Mycobacterium tuberculosis]
GTGTCACGGACCAACATCGAGATCGACGACGAACTCGTGGCCGCCGCACAGCGGATGTACCGACTCGATTCCAAGCGAAG
TGCCGTCGACCTCGCGCTGCGCCGGCTCGTGGGTGAACCGTTGGGCCGCGATGAGGCTTTGGCGCTGCAGGGCAGCGGTT
TCGACTTCAGCAACGATGAGATCGAATCGTTCTCGGATACGGACCGCAAGCTCGCCGACGAGTCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LVU0

Antitoxin

Source ID Structure
AlphaFold DB E3PJ72

References