Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 803669..804504 Replicon chromosome
Accession NZ_CP053281
Organism Escherichia coli strain SCU-308

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag HHJ45_RS03930 Protein ID WP_042966375.1
Coordinates 803669..804046 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A7W3AJG7
Locus tag HHJ45_RS03935 Protein ID WP_001389198.1
Coordinates 804136..804504 (-) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ45_RS03895 798748..799353 + 606 WP_001255030.1 type II secretion system minor pseudopilin GspJ -
HHJ45_RS03900 799350..800327 + 978 WP_000633239.1 type II secretion system minor pseudopilin GspK -
HHJ45_RS03905 800324..801502 + 1179 WP_000094989.1 type II secretion system protein GspL -
HHJ45_RS03910 801504..802040 + 537 WP_000942795.1 GspM family type II secretion system protein YghD -
HHJ45_RS03915 802323..803165 - 843 Protein_768 DUF4942 domain-containing protein -
HHJ45_RS03920 803250..803447 - 198 WP_085949090.1 DUF957 domain-containing protein -
HHJ45_RS03925 803475..803672 - 198 Protein_770 hypothetical protein -
HHJ45_RS03930 803669..804046 - 378 WP_042966375.1 TA system toxin CbtA family protein Toxin
HHJ45_RS03935 804136..804504 - 369 WP_001389198.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HHJ45_RS03940 804584..804805 - 222 WP_001405861.1 DUF987 domain-containing protein -
HHJ45_RS03945 804874..805350 - 477 WP_001186724.1 RadC family protein -
HHJ45_RS03950 805366..805851 - 486 WP_032270302.1 antirestriction protein -
HHJ45_RS03955 805943..806761 - 819 WP_042970615.1 DUF945 domain-containing protein -
HHJ45_RS03960 806851..807084 - 234 WP_001278282.1 DUF905 family protein -
HHJ45_RS03965 807090..807767 - 678 WP_001097567.1 hypothetical protein -
HHJ45_RS03970 807918..808598 - 681 WP_001282912.1 WYL domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - gspC / gspD / gspE / gspF / gspG / gspH / gspI / gspJ / gspK / gspL / gspM 718465..850626 132161


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(18-117)


Sequences


Toxin        


Download         Length: 126 a.a.        Molecular weight: 14074.15 Da        Isoelectric Point: 8.2904

>T156493 WP_042966375.1 NZ_CP053281:c804046-803669 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDLPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T156493 NZ_CP069066:c695361-694948 [Mycobacterium tuberculosis]
GTGAAACCGCCGCTGGCAGTGGACACCAGCGTCGCGATTCCGTTGCTGGTACGGACCCATACCGCGCATGCGGCGGTTGT
CGCCTGGTGGGCACATCGGGAGGCCGCGCTGTGCGGGCACGCCCTGGCCGAAACCTACTCCGTGCTGACCCGCCTGCCGC
GTGACCTACGACTGGCACCGATGGACGCCGCGCGGCTTCTTACCGAACGCTTTGCGGCACCGCTGTTGTTGAGTTCCCGC
ACCACTGAACATCTCCCACGCGTGCTGGCCCAATTCGAGATCACTGGTGGCGCGGTCTATGACGCTCTCGTGGCCCTTGC
CGCCGCCGAGCACCGGGCTGAACTCGCCACACGCGATGCTCGAGCCAAGGACACTTACGAAAAGATCGGCGTCCACGTCG
TTGTCGCCGCGTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13610.39 Da        Isoelectric Point: 6.3159

>AT156493 WP_001389198.1 NZ_CP053281:c804504-804136 [Escherichia coli]
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT156493 NZ_CP069066:c695594-695358 [Mycobacterium tuberculosis]
ATGAAGGCTGTTGTGGATGCGGCTGGCCGCATCGTCGTACCCAAACCGCTGCGCGAAGCCTTGGGGCTGCAACCGGGGTC
CACCGTGGAAATATCCCGCTATGGCGCTGGTCTCCACCTGATTCCCACCGGACGAACAGCGCGTCTCGAAGAGGAGAATG
GCGTACTGGTGGCCACCGGTGAGACCACGATCGACGATGAGGTCGTGTTCGGCCTTATCGATAGCGGCCGGAAGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A7W3AJG7

References