Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2441899..2442421 Replicon chromosome
Accession NZ_CP053245
Organism Escherichia coli strain SCU-485

Toxin (Protein)


Gene name relE Uniprot ID V0VCV4
Locus tag HHJ54_RS11405 Protein ID WP_001105537.1
Coordinates 2442131..2442421 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0SC69
Locus tag HHJ54_RS11400 Protein ID WP_000212715.1
Coordinates 2441899..2442141 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ54_RS11380 2437610..2438983 + 1374 WP_001219792.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase -
HHJ54_RS11385 2439141..2439692 - 552 WP_000166276.1 ribosome-associated protein -
HHJ54_RS11390 2439786..2441138 + 1353 WP_001162187.1 metalloprotease PmbA -
HHJ54_RS11395 2441321..2441707 + 387 WP_001232246.1 cytochrome b562 -
HHJ54_RS11400 2441899..2442141 + 243 WP_000212715.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HHJ54_RS11405 2442131..2442421 + 291 WP_001105537.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HHJ54_RS11410 2442422..2442886 - 465 WP_001106233.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HHJ54_RS11415 2443044..2445182 - 2139 WP_000187799.1 anaerobic ribonucleoside-triphosphate reductase -
HHJ54_RS11420 2445576..2447231 - 1656 WP_001338059.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11383.19 Da        Isoelectric Point: 9.8531

>T156364 WP_001105537.1 NZ_CP053245:2442131-2442421 [Escherichia coli]
MNYELTFDPRALKEWQKLGVTVREQFKKKLEDALKRPRNPSAKLRDLPDCYKIKLRTQGYRLVYQVNDKELLVLVIAIGK
RENSAVYEDADKRLDE

Download         Length: 291 bp

>T156364 NZ_CP069063:c3105445-3105089 [Mycobacterium tuberculosis]
GTGATGCGCCGCGGTGAGATTTGGCAGGTCGATCTCGACCCCGCTCGAGGTAGCGAAGCGAACAACCAGCGCCCCGCCGT
CGTCGTCAGCAACGACCGGGCCAACGCGACCGCCACGCGTCTTGGGCGCGGCGTCATCACCGTCGTGCCGGTGACGAGCA
ACATCGCCAAGGTCTATCCGTTTCAGGTGTTGTTGTCGGCCACCACTACTGGTCTCCAGGTCGACTGCAAGGCGCAGGCC
GAGCAAATCAGATCGATTGCTACCGAGCGGTTGCTCCGGCCAATCGGCCGAGTTTCAGCCGCCGAACTTGCCCAGCTCGA
TGAGGCTTTGAAACTGCATCTCGACTTATGGTCGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9125.56 Da        Isoelectric Point: 5.1369

>AT156364 WP_000212715.1 NZ_CP053245:2441899-2442141 [Escherichia coli]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL

Download         Length: 243 bp

>AT156364 NZ_CP069063:c3105659-3105429 [Mycobacterium tuberculosis]
GTGAAGTTGAGCGTGAGCCTGTCCGATGACGACGTCGCGATCCTGGACGCATATGTGAAACGAGCGGGATTACCATCCCG
CTCCGCCGGCCTGCAGCATGCGATCCGCGTGCTTCGCTACCCCACGCTCGAAGATGACTATGCCAACGCATGGCAAGAAT
GGTCGGCAGCCGGCGACACGGACGCGTGGGAGCAGACCGTCGGCGACGGAGTCGGTGATGCGCCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0VCV4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9H4B3

References