Detailed information of TA system TA155986

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 4338848..4339106
• Replicon: chromosome
• Accession: NZ_CP053080
• Organism: Escherichia coli strain HB37

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: HKW69_RS20855
• Protein ID: WP_000809168.1
• Coordinates: 4338954..4339106 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	4338848..4338905 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HKW69_RS20840	4334677..4335936	-	1260	WP_000494927.1	hypothetical protein	-
HKW69_RS20845	4336065..4337558	-	1494	WP_001314416.1	sulfatase-like hydrolase/transferase	-
HKW69_RS20850	4337578..4338339	-	762	WP_001274828.1	hypothetical protein	-
-	4338848..4338905	-	58	-	-	Antitoxin
HKW69_RS20855	4338954..4339106	+	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
HKW69_RS20860	4339211..4340341	-	1131	WP_001118464.1	molecular chaperone DnaJ	-
HKW69_RS20865	4340430..4342346	-	1917	WP_000516135.1	molecular chaperone DnaK	-
HKW69_RS20870	4342718..4343122	+	405	WP_000843689.1	DUF2541 family protein	-
HKW69_RS20875	4343148..4343861	+	714	WP_001102393.1	acidic protein MsyB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T155986 WP_000809168.1 NZ_CP053080:4338954-4339106 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T155986 NZ_CP068822:c3651150-3650848 [Escherichia coli]
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT155986 NZ_CP053080:c4338905-4338848 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin