Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 984232..984794 Replicon chromosome
Accession NZ_CP052884
Organism Gordonia ajococcus strain A2

Toxin (Protein)


Gene name relE Uniprot ID A0A290XKJ4
Locus tag GAA2_RS04530 Protein ID WP_006438782.1
Coordinates 984232..984522 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7J5WZ76
Locus tag GAA2_RS04535 Protein ID WP_006438783.1
Coordinates 984519..984794 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GAA2_RS04510 979289..980921 + 1633 Protein_888 long-chain fatty acid--CoA ligase -
GAA2_RS04515 981791..982126 - 336 WP_081598291.1 hypothetical protein -
GAA2_RS04520 982791..983810 - 1020 WP_191834753.1 IS481 family transposase -
GAA2_RS04525 983925..984190 - 266 Protein_891 hypothetical protein -
GAA2_RS04530 984232..984522 - 291 WP_006438782.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GAA2_RS04535 984519..984794 - 276 WP_006438783.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GAA2_RS04540 985238..985606 + 369 WP_191834754.1 DUF5313 family protein -
GAA2_RS04545 986737..987000 + 264 WP_191834755.1 helix-turn-helix domain-containing protein -
GAA2_RS04550 987034..987666 + 633 WP_191834756.1 DDE-type integrase/transposase/recombinase -
GAA2_RS04555 987709..988434 + 726 WP_191834757.1 peroxiredoxin -
GAA2_RS04560 988510..988755 - 246 WP_191834758.1 hypothetical protein -
GAA2_RS04565 988964..989698 - 735 WP_191834759.1 ZIP family metal transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(14-94)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10789.30 Da        Isoelectric Point: 11.1310

>T155726 WP_006438782.1 NZ_CP052884:c984522-984232 [Gordonia ajococcus]
MSDAPTDSPAPYRVEVASPARRDLQRLPSRIVHAVIEFISGPLAGNPHRLSKPLRNDLAGLHSARRGDYRVLLRIDDPNH
TIVVVRIDHRAHAYRT

Download         Length: 291 bp

>T155726 NZ_CP068812:c5179337-5179230 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 9740.91 Da        Isoelectric Point: 4.6221

>AT155726 WP_006438783.1 NZ_CP052884:c984794-984519 [Gordonia ajococcus]
MTTVPLGEAKDKLSALVDSAETTHDIITITKHGKPAAVLMSADDLESLHETIYWLSRAGVRDDVATADAEYAAGHTVSID
DLRAEHGMPPK

Download         Length: 276 bp

>AT155726 NZ_CP068812:5179384-5179450 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A290XKJ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7J5WZ76

References