Detailed information of TA system TA155648

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/HTH_IclR(antitoxin)
• Location: 5457599..5459307
• Replicon: chromosome
• Accession: NZ_CP052858
• Organism: Pseudomonas sp. ADAK20

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: HKK56_RS24270
• Protein ID: WP_169390037.1
• Coordinates: 5458429..5459307 (-)
• Length: 293 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: A0A1S1UQA4
• Locus tag: HKK56_RS24265
• Protein ID: WP_029289973.1
• Coordinates: 5457599..5458432 (-)
• Length: 278 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HKK56_RS24245	5452807..5454300	-	1494	WP_029289982.1	aldehyde dehydrogenase	-
HKK56_RS24250	5454311..5455114	-	804	WP_104911219.1	aspartate dehydrogenase	-
HKK56_RS24255	5455125..5456807	-	1683	WP_029289977.1	thiamine pyrophosphate-binding protein	-
HKK56_RS24260	5456800..5457597	-	798	WP_154907128.1	SDR family oxidoreductase	-
HKK56_RS24265	5457599..5458432	-	834	WP_029289973.1	IclR family transcriptional regulator	Antitoxin
HKK56_RS24270	5458429..5459307	-	879	WP_169390037.1	alpha/beta hydrolase	Toxin
HKK56_RS24275	5459312..5459851	-	540	WP_029289969.1	cupin domain-containing protein	-
HKK56_RS24280	5459865..5460632	-	768	WP_169390036.1	SDR family oxidoreductase	-
HKK56_RS24285	5460629..5461402	-	774	WP_029289965.1	ABC transporter permease	-
HKK56_RS24290	5461431..5462423	-	993	WP_169390035.1	ABC transporter substrate-binding protein	-
HKK56_RS24295	5462463..5463314	-	852	WP_029289961.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Alpha/beta hydrolase fold-1 (45-276)

Antitoxin

• Transcription regulator IclR, C-terminal (136-256)

Sequences

Toxin

Protein

• Length: 293 a.a.
• Molecular weight: 30849.42 Da
• Isoelectric Point: 8.5086

>T155648 WP_169390037.1 NZ_CP052858:c5459307-5458429 [Pseudomonas sp. ADAK20]
MLPGLTQAAPTAHLQAQLQRDFPQQLVASAGGQQALRVCGTGPAVVLLHGIGSGAASWLQVAQHLAAQARVIAWDAPGYG
DSSPLESQVPKAEQYAARLVQMLDALQVDECVLVGHSLGALTALALARSAQAKRVSRLVLISPARGYGAPERSPQRQQVR
QQRLDNLQRLGIAGLAAQRSAHMLSPRAQPEALAWVHWNMARLNPPGYRQAIELLCGDDLLRHGQPAMPCDVHCGEADAI
TTPDTCLGVAKALGASFNLIADAGHASPIEQPLVVAGRLAYALKQSLTGRTL

Nucleotide

• Length: 879 bp

>T155648 NZ_CP068810:1300214-1300525 [Escherichia coli]
ATGCACATCATTTCGAAAGCGCCATTTGAAGAGTGTGCGCGCAAATATCCTAACGACGCTCTGGCTCTACACTCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACACCAGAAGAAATGCGAACGGCGTTTCCTAACCTCGACAATTTTAAATATC
GCAACAAATGGTACGTTCTGGATGTCGGCGGGAACAATCTTAGGGTTATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACGAATCACGCAGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA

Antitoxin

Protein

• Length: 278 a.a.
• Molecular weight: 30761.23 Da
• Isoelectric Point: 6.4976

>AT155648 WP_029289973.1 NZ_CP052858:c5458432-5457599 [Pseudomonas sp. ADAK20]
MNDSDLLKDAQDKYIVPGLERGLLLLCEFSRRNRTLTAPELARRLALPRSTIFRLLTTLETMGFVTRSGNEYRLGMSVLR
LGFEYLASLELTELGQPLLARLCDRVNYPSNLVVRDGRSIVYVAKVSPPSVFSNAVNVGTRLPAHATVLGRILLEDLSLA
ELRELYPEEHLEQHSHCTPKTVMELFDLLQADRQRGFVSGEGFFESAISTVAAPVRDQSGDIVAALGVTIPTTQIGHVNF
EELLTQVRRSADELSRLLNYNGGAHSGQPRVTALMRD

Nucleotide

• Length: 834 bp

>AT155648 NZ_CP068810:1300522-1300941 [Escherichia coli]
ATGACTGCTAATGCTGCACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGCAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGACACCAATCCACTTATCGACTTTC
TGGCGAGCCGCATTGCAGAATATGAAAACAACAACGAAAAGTTTGCAGAGTTCGACAAAGCCGTTGCAGCAATGCCGGTT
GGCGTGGCCTTACTTCGTACGCTGATTGATCAACATAATTTGACCTATGCGGATTTGAAGAACGAAATCGGCTCTAAATC
TCTGGTCAGTCAGATTTTGTCTGGGCAACGATCCCTGACGATATCCCATATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA

Structures

Antitoxin

• AlphaFold DB: A0A1S1UQA4