Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA(toxin)
Location 1420261..1420874 Replicon chromosome
Accession NZ_CP052858
Organism Pseudomonas sp. ADAK20

Toxin (Protein)


Gene name hicA Uniprot ID A0A1S1UTY1
Locus tag HKK56_RS06500 Protein ID WP_029293161.1
Coordinates 1420623..1420874 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A1S1UV42
Locus tag HKK56_RS06495 Protein ID WP_070995596.1
Coordinates 1420261..1420626 (-) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HKK56_RS06475 1415615..1416766 + 1152 WP_092235435.1 HlyD family secretion protein -
HKK56_RS06480 1416756..1418279 + 1524 WP_169391146.1 multidrug efflux MFS transporter -
HKK56_RS06485 1418360..1418944 - 585 WP_070995594.1 TetR/AcrR family transcriptional regulator -
HKK56_RS06490 1419087..1420259 + 1173 WP_169391145.1 MFS transporter -
HKK56_RS06495 1420261..1420626 - 366 WP_070995596.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HKK56_RS06500 1420623..1420874 - 252 WP_029293161.1 type II toxin-antitoxin system HicA family toxin Toxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-76)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9408.00 Da        Isoelectric Point: 9.6951

>T155645 WP_029293161.1 NZ_CP052858:c1420874-1420623 [Pseudomonas sp. ADAK20]
VSKNEKLLAKLLNLQMAFTWPELVTLLGWLGYRQIEGAGSRVKFDIGDPSAMITLHKPHPGNELKHYIRRQIIEQLESGG
LLQ

Download         Length: 252 bp

>T155645 NZ_CP068810:c904678-904301 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13246.06 Da        Isoelectric Point: 6.9569

>AT155645 WP_070995596.1 NZ_CP052858:c1420626-1420261 [Pseudomonas sp. ADAK20]
MSNQLKYKGYIGSIEASVEDNCLFGKLLFIRALVSYEGQTVAQLEAAFREAVEDYLTTCQTLGQAPEKPCKGSFNVRVGH
DLHLAAALAATQKKVTLNDLTRQALNEFLRHHAADSHPALG

Download         Length: 366 bp

>AT155645 NZ_CP068810:c905099-904725 [Escherichia coli]
GTGTCAGACACACACCCCGGGACAACGCATCCCGACAACAACAACGACCGCCCCTGGTGGGGGCTCCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGGGGGCAGT
TTAGCGACGCGGATGCGTATCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1S1UTY1

Antitoxin

Source ID Structure
AlphaFold DB A0A1S1UV42

References